Technology
Publications
The following posters and presentations regarding OncoSec’s technology and clinical data have been presented at several scientific conferences and meetings
AACR 2019 – Intratumoral Electroporation of Plasmid Il-12 And Cxcl9 With Membrane-Bound Anti-CD3 Elicits Robust Anti-Tumor Immunity
SABCS 2018 – Intratumoral tavokinogene telseplasmid and electroporation in pre-treated inoperable locally advanced or recurrent triple-negative breast cancer
SITC 2018 – Initial report of intratumoral tavokinogene telseplasmid with pembrolizumab in advanced melanoma:an approach designed to convert PD-1 antibody progressors into responders (NCT03132675)
Clinical and biomarker analyses of a phase II study of intratumoral tavokinogene telseplasmid (pIL-12) plus pembrolizumab in stage III/IV melanoma patients predicted to not respond to anti-PD-1SITC 2017
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Intratumoral Administration Of A Multigene Construct By Electroporation Can Effectively Modulate Anti-Tumor Response In A Murine B16.f10 Model
Clinical Immune Monitoring and Biomarker Data of TAVO Monotherapy Compared to TAVO with Pembrolizumab in Metastatic Melanoma Supports the Rationale for Combination Therapy
9th Annual World Congress of Melanoma – A Joint Meeting with the Society of Melanoma Research
Intratumoral Delivery of a P2A-linked Bicistronic IL-12 Construct Leads to High Intratumoral Expression and Systemic Anti-tumor Response
American Association of Cancer Research (AACR) Annual Meeting 2017
Intratumoral Electroporation-Mediated IL-12 Gene Therapy can Enhance Tumor Immunogenicity
Keystone Symposia Conference “Cancer Immunology and Immunotherapy: Taking a Place in Mainstream Oncology” 2017
Immune Monitoring Outcomes of Patients with Stage III/IV Melanoma Treated with a Combination of Pembrolizumab and Intratumoral Plasmid Interleukin 12 (pIL-12)
ASCO-SITC 2017
Phase II Study of Intratumoral Plasmid Interleukin 12 (pIL-12) with Electroporation
SITC 2016
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Intratumoral IL-12 Therapy in HNSCC
EUROGIN 2016
A Novel Applicator for Endoscopic Gene Electro-Transfer
AACR Engineering and Physical Sciences in Oncology
Feedback Optimized Gene Electro-Transfer for Immunotherapy
AACR Engineering and Physical Sciences in Oncology
Priming response to anti-PD1/PDL1 blockade with intratumoral electroporation of plasmid IL-12 in advanced melanoma
American Association for Cancer Research Annual Meeting 2016
In vivoIntratumoral Electroporation of Gp96-Ig/Fc-OX40L Stimulates CD8+ T cell Cross Priming to Tumor-Specific Neoantigens
American Association for Cancer Research Annual Meeting 2016
Intratumoral Delivery of Interleukin-12 DNA via In Vivo Electroporation Leads to Regression of Injected and Non-Injected Tumors in Merkel Cell Carcinoma
2015 European Cancer Congress
Development of a Catheter-Based Applicator for Immuno-Oncology
First World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food & Environmental Technologies
Advances in Clinical Electroporation: Tissue Sensing, Feedback Control, and Catheter Technology
First World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food & Environmental Technologies
Immune Correlates of Intratumoral IL-12 Electroporation
European Society for Medical Oncology 2014 Annual Meeting
Systemic Anti-Tumor Effect and Clinical Response in a Phase 2 Trial of Intratumoral Electroporation of Plasmid Interleukin-12 in Patients with Advanced Melanoma
American Society of Clinical Oncology 2014 Annual Meeting
Intratumoral electroporation of plasmid interleukin-12: efficacy and biomarker analyses from a phase 2 study in melanoma (OMS-I100)
Melanoma Bridge Meeting 2014