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OncoSec’s Cancer Clinical Trial Strategy Featured in BioWorld Magazine

Article Highlights OncoSec’s Entry Into Three Phase II Trials for Skin Cancer

SAN DIEGO, CA, August 15, 2011 — OncoSec Medical Incorporated (OTCBB: ONCS), which is developing its advanced-stage OMS ElectroOncology therapies to treat solid tumor cancers, announced today that a profile of the company and its pipeline of oncology therapies is featured in the most recent issue of BioWorld, one of the most widely read publications in the pharma and biotech industries. The article can be purchased at www.bioworld.com.

The publication noted that: “The San Diego-based biotech has yet to celebrate its first anniversary, but its lead electro immunotherapy candidate, DNA IL-12, is heading into three Phase II trials for melanoma, Merkel cell carcinoma and cutaneous T-cell lymphoma (CTCL). The company attributes its enviable maturity to its March spin-out from Inovio Pharmaceuticals Inc., of Blue Bell, Pa. The move allowed Inovio to focus on DNA vaccines, while giving OncoSec the opportunity to develop electrochemical and cytokine-based immune therapies for treating solid tumors via electroporation delivery.”

A previous Phase I trial provided further evidence that a DNA plasmid encoded to produce IL-12 delivered by electroporation into melanoma lesions induces responses to known and novel antigens, resulting in regression of local treated lesions as well as distant untreated lesions The link below provides further information on this trial:(http://www.oncosec.com/news/oncosec-electroimmunotherapy-shows-systemic-effects-of-metastatic-melanoma-tumor-in-more-than-50-percent-of-patients).

OncoSec’s President and CEO, Punit Dhillon said, “We are pleased to receive recognition from a global biotech publication for OncoSec’s lead pipeline immunotherapeutic product. We look forward to reporting additional progress from our Phase II skin cancer trials in Q4.”

About BioWorld Today®

BioWorld® Today, the news source of record for the biotechnology industry, is read by biotechnology professionals worldwide for its hard-hitting, objective news reporting. BioWorld Today is delivered via e-mail every business morning, and is also found exclusively online at www.bioworld.com. The BioWorld online web site has been internationally recognized as the most comprehensive resource for strategic biotechnology news and information available today.

About OncoSec Medical Inc.

OncoSec Medical (OTCBB: ONCS) develops novel ElectroOncology therapies that combine its proprietary electroporation delivery technology with a chemotherapeutic or novel DNA-based immunotherapeutics. Targeted local delivery of these agents is designed to achieve selective destruction of cancerous tumors while sparing healthy normal tissue, resulting in improved functional, cosmetic and quality of life outcomes. These therapies have achieved validating safety and efficacy data in early and late stage clinical studies of over 400 cancer patients. OncoSec’s clinical programs include three Phase II clinical trials. More information is available at www.oncosec.com.

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This press release contains forward looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Any statements in this release that are not historical facts may be considered such “forward looking statements.” Forward looking statements are based on management’s current preliminary expectations and are subject to risks and uncertainties which may cause our results to differ materially and adversely from the statements contained herein. Some of the potential risks and uncertainties that could cause actual results to differ from those predicted include our ability to raise additional funding, our ability to acquire, develop or commercialize new products, uncertainties inherent in pre-clinical studies and clinical trials, unexpected new data, safety and technical issues, competition and market conditions. These and additional risks and uncertainties are more fully described in OncoSec’s filings with the Securities and Exchange Commission. Undue reliance should not be placed on forward looking statements which speak only as of the date they are made. OncoSec disclaims any obligation to update any forward looking statements to reflect new information, events or circumstances after the date they are made, or to reflect the occurrence of unanticipated events.

OncoSec Medical to Present at DNA Vaccines Conference 2011

SAN DIEGO, Ca., July 11, 2011 — OncoSec Medical Incorporated (OTCBB: ONCS), which is developing its advanced-stage OMS ElectroOncology therapies to treat solid tumor cancers, announced today that the company will present at the Annual DNA Vaccines Conference, hosted by the International Society of DNA Vaccines July 12-14 at the Loews Coronado Bay hotel in San Diego, California. This year’s conference is themed, “Building on Clinical Progress and Exploring New Targets”.

Richard Heller, Ph.D., director of the Frank Reidy Research Center for Bioelectrics at Old Dominion University and eminent leader in the field of electroporation, as well as Adil Daud, M.D., co-director of the Melanoma Center at the University of California, San Francisco, and principal investigator for OncoSec’s upcoming Phase II melanoma clinical trial will be presenting at the 2011 DNA Vaccines Conference on behalf of OncoSec.

Richard Heller, PhD – Director and Professor, Frank Reidy Research Center for Bioelectrics

“Immunotherapy for Cancer Facilitated by Electro Gene Transfer”
July 14, 2011
2:00 – 2:30 PM

Adil Daud, MD – Clinical Professor of Medicine, University of California, San Francisco

Electroporative “Gene Therapy with IL-12 Plasmid in Metastatic Melanoma”
July 14, 2011
2:30 – 3:00pm

About OncoSec Medical Inc.

OncoSec Medical (OTCBB: ONCS) develops novel ElectroOncology therapies that combine its proprietary electroporation delivery technology with a chemotherapeutic or novel DNA-based immunotherapeutics. Targeted local delivery of these agents is designed to achieve selective destruction of cancerous tumors while sparing healthy normal tissue, resulting in improved functional, cosmetic and quality of life outcomes. These therapies have achieved validating safety and efficacy data in early and late stage clinical studies of over 400 cancer patients. OncoSec’s clinical programs include three Phase II clinical trials. More information is available at www.oncosec.com.

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This press release contains forward looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Any statements in this release that are not historical facts may be considered such “forward looking statements.” Forward looking statements are based on management’s current preliminary expectations and are subject to risks and uncertainties which may cause our results to differ materially and adversely from the statements contained herein. Some of the potential risks and uncertainties that could cause actual results to differ from those predicted include our ability to raise additional funding, our ability to acquire, develop or commercialize new products, uncertainties inherent in pre-clinical studies and clinical trials, unexpected new data, safety and technical issues, competition and market conditions. These and additional risks and uncertainties are more fully described in OncoSec’s filings with the Securities and Exchange Commission. Undue reliance should not be placed on forward looking statements which speak only as of the date they are made. OncoSec disclaims any obligation to update any forward looking statements to reflect new information, events or circumstances after the date they are made, or to reflect the occurrence of unanticipated events.

OncoSec Medical Reports Third Quarter 2011 Financial Results

SAN DIEGO, Ca, June 15, 2011 — OncoSec Medical Incorporated (OTCBB: ONCS), which is developing its advanced-stage ElectroOncology therapies to treat solid tumor cancers, today reported financial results for the quarter ended April 30, 2011.

Total operating expenses for the three and nine months ended April 30, 2011, were $496,000 and $503,000 as compared to $3,000 and $15,000 for the three and nine months ended April 30, 2010.

The net loss attributable to common stockholders for the three and nine months ended April 30, 2011, was $499,000, or $0.01 per share, and $506,000, or $0.01 per share, as compared with a net loss attributable to common stockholders of $3,000, or $0.00 per share, and $15,000, or $0.00 per share, for the three and nine months ended April 30, 2010.

Operating Expenses

Research and development expenses for the three and nine months ended April 30, 2011, were $217,000 and $217,000 as compared to $0 for both the three and nine months ended April 30, 2010. The increase in research and development expenses for the comparable three month and nine month periods was due to our shift in focus from the online inventory services industry to the biomedical industry, which occurred in conjunction with the previously announced closing on March 24, 2011 of the asset purchase agreement with Inovio Pharmaceuticals, Inc. (Inovio) to acquire certain technology and related assets. The technology and related assets embodied in the asset purchase agreement relate to the use of drug-medical device combination products for the treatment of different cancers.

General and administrative expenses for the three and nine months ended April 30, 2011, were $280,000 and $287,000 as compared to $3,000 and $15,000 for the three and nine months ended April 30, 2010. The increase for the comparable three and nine month periods was due to an increase in salary, legal and other expenses associated with the increase in operations stemming from our shift in focus to the biomedical industry.

Net Loss Attributable to Common Stockholders

The $491,000 increase in net loss attributable to common stockholders for the nine months ended April 30, 2011, compared with the same period in 2010, resulted from our shift in focus to be a biomedical company concentrated on developing cancer therapeutic products.

Capital Resources

As of April 30, 2011, our cash balance was $543,000, compared to $237 as of July 31, 2010. This change primarily resulted from an increase in cash resulting from proceeds of $1,092,000 we received in connection with a private placement of common stock announced on March 18, 2011. This was offset by the initial scheduled payment of $250,000 made to Inovio during March 2011, in accordance with the Asset Purchase Agreement, and operating expenses incurred during the nine month period ended April 30, 2011. With this private placement, we issued 1,456,000 units at a purchase price of $0.75 per unit for gross proceeds of $1,092,000. Each unit consisted of one share of common stock and one share purchase warrant entitling the holder to acquire one share of common stock at a price of $1.00 per share for a period of five years from the closing of the private placement.

Stockholders Equity (Deficit)

As of April 30, 2011, we had a stockholder’s equity balance of $556,000 compared to a deficit balance of $30,000 at July 31, 2010, and also had 52,656,000 and 68,480,000 shares of common stock issued and outstanding for the same respective periods.

Corporate Update

Corporate Development

In this quarter, OncoSec purchased certain non-DNA vaccine technology and intellectual property from Inovio relating to electroporation delivery of chemotherapeutic agents and nucleic acids encoding cytokines for the treatment of solid tumors. Pursuant to the agreement, OncoSec made an upfront payment of $250,000 and will pay up to an additional amount of $2.75 M by March 24, 2013, based on achievement of milestones. OncoSec will also pay Inovio royalties based on commercial product sales.

Clinical Development

OncoSec announced that it will initiate three Phase II clinical trials to evaluate its lead ElectroImmunotherapy technology, DNA IL-12 locally delivered using electroporation, in patients with melanoma, Merkel cell carcinoma and cutaneous T-cell lymphoma. The company is building on positive Phase I dose-escalation trial results in 24 patients with metastatic melanoma. This previous study demonstrated that treatment with DNA IL-12 in conjunction with electroporation was safe and well tolerated, and suggested a systemic objective response in more than half of the subjects, 15% of patients showing 100% clearance of distant, untreated tumors. Each respective trial will be run under a physician-sponsored IND. These studies are expected to start before the end of 2011.

About OncoSec Medical Inc.

Oncosec Medical (OTCBB: ONCS) develops novel ElectroOncology therapies that combine its proprietary electroporation delivery technology with a chemotherapeutic or novel DNA-based immunotherapeutics. Targeted local delivery of these agents is designed to achieve selective destruction of cancerous tumors while sparing healthy normal tissue, resulting in improved functional, cosmetic and quality of life outcomes. These therapies have achieved validating safety and efficacy data in early and late stage clinical studies of over 400 cancer patients. OncoSec’s clinical programs include three Phase II clinical trials. More information is available at www.oncosec.com.

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This press release contains forward looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Any statements in this release that are not historical facts may be considered such “forward looking statements.” Forward looking statements are based on management’s current preliminary expectations and are subject to risks and uncertainties which may cause our results to differ materially and adversely from the statements contained herein. Some of the potential risks and uncertainties that could cause actual results to differ from those predicted include our ability to raise additional funding, our ability to acquire, develop or commercialize new products, uncertainties inherent in pre-clinical studies and clinical trials, unexpected new data, safety and technical issues, competition and market conditions. These and additional risks and uncertainties are more fully described in OncoSec’s filings with the Securities and Exchange Commission. Undue reliance should not be placed on forward looking statements which speak only as of the date they are made.OncoSec disclaims any obligation to update any forward looking statements to reflect new information, events or circumstances after the date they are made, or to reflect the occurrence of unanticipated events.

OncoSec Announces Clinical Leadership Appointments

Cancer therapeutic company expands clinical team to lead its Phase II ElectroOncology programs

SAN DIEGO, Ca, June 14, 2011 — OncoSec Medical Inc. (OTCBB: ONCS), which is developing its advanced-stage ElectroOncology therapies to treat solid tumor cancers, announced today two appointments to its clinical team who will lead the clinical operations of OncoSec’s ElectroOncology therapies.

Punit Dhillon, OncoSec’s President and CEO, said, “OncoSec has been preparing for its three ElectroOncology clinical studies, which we will launch in the second half of the year, with our in-house leaders and top-tier clinical advisory panel. These new appointments round out our clinical team with additional strategic experience and resources with full focus on advancing these important skin cancer trials. Dr. Goldfarb is a pre-eminent leader in the field of ElectroChemotherapy and Mr. Kitt is a dynamic leader with numerous successes in effectively and efficiently managing clinical trials to completion. We welcome them to the OncoSec team.”

Dr. Paul Goldfarb, M.D., F.A.C.S., Medical Director

Dr. Goldfarb will be advising the Company’s clinical and regulatory affairs department on all clinical programs. He is a surgical oncologist who has been in private practice in San Diego for over 27 years and a practicing physician for over 40 years. He trained in general surgery at Albert Einstein College of Medicine and in surgical oncology at the Memorial Hospital for Cancer and Allied Diseases and Sloan Kettering Institute for Cancer in New York City, and focuses his practice on the surgical management of cancer. He is currently Clinical Associate Professor of Surgery at the University of California at San Diego, and Associate Medical Director of Oncology at Scripps Health. He has authored numerous peer-reviewed articles related to the use of electroporation to deliver bleomycin in solid tumors and other ablative technologies for the treatment of cancer. In addition to his private practice in San Diego, he is an active volunteer in the American Cancer Society, where he was on the national board after having been president of the California Division and the San Diego unit. He helped organize the first camp in California for children with cancer, chaired a committee that established guidelines for the management of common cancer, and organized a meeting to address the role of a voluntary health agency and a managed health care environment in California. Dr. Goldfarb has been a member of the Health Benefit Subcommittee of CALPERS, which reviews outcomes and outcome measures to be used in assessing the quality of health management organizations.

Dr. Goldfarb said, “I have treated and observed the frequently detrimental effects of the front-line treatment of solid tumors, which is surgery, in many thousands of patients over many decades. Physicians, patients and payors would welcome a new therapy to complement and ideally replace surgery by more selectively killing cancerous cells while being less invasive and more cost effective. I look forward to being able to champion OncoSec’s technologies, which have these attributes, and help guide them toward commercialization.”

Ernest Kitt, Executive Director, Clinical Operations

Ernest Kitt brings to OncoSec more than 15 years of industry experience in clinical research and operations. Prior to joining OncoSec, he managed clinical operations for early and late stage oncology programs for established biotechnology companies including Medicinova and Vical. Mr. Kitt has also worked in a management capacity for clinical research organizations (CROs), where he managed project directors, senior project managers and clinical research associates for domestic and international clinical programs.

About OncoSec Medical Inc.

OncoSec’s minimally invasive ElectroOncology therapies utilize its proprietary electroporation delivery system, called the OncoSec Medical System (OMS), which applies short electrical impulses to selectively targeted tumors and tissue in order to significantly increase the ability of anti-cancer chemotherapeutic or biologic agents to enter into cells. These treatments selectively destroy cancer cells while preserving healthy tissue. They optimize required dosage and potentially reduce treatment and post-treatment costs. The company has two medical paths employing its drug/device technology:

  • OncoSec’s ElectroChemotherapy approach uses the OMS to enable significant uptake by cells of a chemotherapeutic agent which then selectively kills cancerous cells. As opposed to surgery, this therapeutic approach allows for treatment of the margin without removing healthy tissue, providing beneficial appearance, organ function and quality of life outcomes.
  • OncoSec’s ElectroImmunotherapy approach uses the OMS to deliver a DNA-based therapy intended to induce a host immune response capable of killing cancerous cells. The objective of this therapy is to stimulate and recruit the body’s immune system to selectively kill cancer cells in a local treatment area as well as systemically in distant, untreated metastatic tumors.

About OncoSec Medical Inc.

Oncosec Medical (OTCBB: ONCS) develops novel ElectroOncology therapies that combine its proprietary electroporation delivery technology with a chemotherapeutic or novel DNA-based immunotherapeutics. Targeted local delivery of these agents is designed to achieve selective destruction of cancerous tumors while sparing healthy normal tissue, resulting in improved functional, cosmetic and quality of life outcomes. These therapies have achieved validating safety and efficacy data in early and late stage clinical studies of over 400 cancer patients. OncoSec’s clinical programs include three Phase II clinical trials. More information is available at www.oncosec.com.

* * *
This press release contains forward looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Any statements in this release that are not historical facts may be considered such “forward looking statements.” Forward looking statements are based on management’s current preliminary expectations and are subject to risks and uncertainties which may cause our results to differ materially and adversely from the statements contained herein. Some of the potential risks and uncertainties that could cause actual results to differ from those predicted include our ability to raise additional funding, our ability to acquire, develop or commercialize new products, uncertainties inherent in pre-clinical studies and clinical trials, unexpected new data, safety and technical issues, competition and market conditions. These and additional risks and uncertainties are more fully described in OncoSec’s filings with the Securities and Exchange Commission. Undue reliance should not be placed on forward looking statements which speak only as of the date they are made. OncoSec disclaims any obligation to update any forward looking statements to reflect new information, events or circumstances after the date they are made, or to reflect the occurrence of unanticipated events.

OncoSec Medical to Initiate Multiple Phase II Skin Cancer Clinical Trials

OncoSec Will Evaluate ElectroImmunotherapy Against Melanoma, Merkel Cell Carcinoma, and Cutaneous T-Cell Lymphoma

Company Attracts Premier Cancer Researchers to Guide Clinical Strategy

SAN DIEGO, CA, May 26, 2011 — OncoSec Medical Incorporated (OTCBB: ONCS), which is developing its advanced-stage ElectroOncology therapies to treat solid tumor cancers, announced today it will initiate three Phase II clinical trials to assess its cancer-destroying, tissue-sparing ElectroImmunotherapy technology in patients with melanoma, Merkel cell carcinoma and cutaneous T-cell lymphoma.

OncoSec’s lead ElectroImmunotherapy candidate for these trials is a DNA plasmid coding for IL-12 that is delivered using electroporation. While the DNA IL-12 immunotherapy is administered locally, results from preclinical and Phase I trials indicated that the therapy was safe, without toxic side effects, and resulted in immune responses that produced both a local and systemic effect against abnormal cells. In the Phase I human study, 15% of patients demonstrated 100% clearance of distant, untreated metastatic melanoma tumors; only 0.25% would normally be expected to clear on their own if left untreated. If OncoSec’s Phase II trials further validate this evidence, the DNA-based IL-12 ElectroImmunotherapy platform would represent an important advancement in the treatment of both local and metastatic cancers.

Punit Dhillon, OncoSec’s President and CEO, said, “OncoSec is moving aggressively into three Phase II trials to evaluate our ElectroImmunotherapy platform using DNA IL-12 to activate both innate and adaptive immune responses to kill cancer cells. We are leveraging an experienced management team, a board of directors composed of recognized business and medical leaders, and a group of internationally eminent scientific researchers as advisors. We look forward to these next steps toward our goal of establishing a broad development pipeline for our ElectroImmunotherapy program and improving the quality of life of patients suffering from the life-altering effects of cancer.”

All three of OncoSec’s Phase II clinical trials will be open label, multi-center trials.

Phase II Melanoma Trial (OMS-I100)

OncoSec’s melanoma trial, entitled “Phase II trial of intratumoral pIL-12 electroporation in advanced stage cutaneous and in transit malignant melanoma,” will be a single dose trial treating approximately 25 patients. The primary endpoint is the objective response rate (local and distant) at six months. Secondary trial endpoints include time to objective response (complete and partial responses), duration of distant response and overall survival. OncoSec is building on positive Phase I dose escalation trial results in 24 patients with metastatic melanoma treated with DNA IL-12 in conjunction with electroporation. That study established safety and tolerability and suggested a systemic objective response in more than half of the subjects; 15% of patients showed 100% clearance of distant, non-treated tumors. Based on historical data, less than 1% of patients would have been expected to see regression in their untreated tumors.

According to the National Cancer Institute, about 70,000 new cases of melanoma are diagnosed each year in the U.S., with an estimated 9,000 deaths annually resulting from this most-widespread cancer. About 850,000 patients are currently afflicted with melanoma in the U.S. Current outcomes for melanoma treated by chemotherapy alone have shown a modest response of short duration; current clinical results for chemotherapy in combination with biologic agents have not proved encouraging due to high toxicity.

OncoSec’s melanoma study is a physician-sponsored trial and will be initiated at the University of California at San Francisco.

Phase II Merkel Cell Carcinoma Trial (OMS-I110)

Merkel cell carcinoma is a lethal but rare skin cancer affecting about 1,500 people each year with 33% mortality rate. Current outcomes to chemotherapy treatment have demonstrated short-lived responses with no clear impact on overall survival. OncoSec’s clinical trial, entitled “A Phase II study of intratumoral injection of interleukin-12 plasmid and in vivo electroporation in patients with Merkel cell carcinoma,” is a single dose, open label trial in 15 patients. The study’s endpoint is DNA IL-12 gene expression in tumor tissue at three to four weeks post-treatment. Secondary endpoints will evaluate objective response rates, time to relapse or progression and overall survival. This study will evaluate the safety and tolerability of DNA IL-12 as a treatment for Merkel cell carcinoma and aims to further validate the findings of the previously referenced Phase I trial in metastatic melanoma patients.

OncoSec’s Merkel cell carcinoma study is a physician-sponsored trial and will be initiated at the University of California at San Francisco and University of Washington.

Phase II Cutaneous T-Cell Lymphoma (OMS-I120)

OncoSec’s ElectroImmunotherapy is a potential new treatment for patients suffering from cutaneous T-cell lymphoma, or CTCL. This rare disease affects about 3,000 people each year. Today’s systemically delivered treatment methods typically result in systemic toxicities that preclude their long-term use of this chronic life-altering disease. Cytokine therapies have shown excellent therapeutic benefit; unfortunately, one of the more promising cytokines, IL-12, results in unwanted toxicity and induces drug resistance with chronic use. OncoSec’s ElectroImmunotherapy will locally deliver low dose DNA IL-12 into the body with the goal of avoiding toxicity while inducing a systemic immune response capable of destroying cancerous cells.

OncoSec’s clinical trial, entitled “Phase II trial of intratumoral IL-12 plasmid electroporation in cutaneous lymphoma,” will be an open label, multi-center study and is expected to enroll at least 27 patients. The trial’s primary endpoint is to assess the objective response rate (both local and distant), with safety and progression-free survival as secondary endpoint measures. The aim for this clinical trial is to provide evidence of the potent immune stimulating effects of OncoSec’s ElectroImmunotherapy treatment using DNA IL-12 and its ability to improve the quality of life for patients suffering from the debilitating effects of cancer.

OncoSec’s CTCL study is a physician-sponsored trial and will be initiated at the University of California at San Francisco and University of Pennsylvania.

Eminent Scientific Advisory Panel

To guide and evaluate these trials, OncoSec has attracted nine senior and respected oncology researchers to provide counsel as part of the company’s scientific advisory panel for its ElectroImmunotherapy clinical program.

Alain Rook, M.D., Director of the Cutaneous Lymphoma Program at the University of Pennsylvania, said: “OncoSec and its novel ElectroImmunotherapy platform can be included in the recent coming-of-age for novel immunotherapy treatments demonstrated by the recent approval of Provenge, Ipilumimab and new agents on the horizon such as cancer metabolism and cancer stem cells.”

The full panel consists of:

  • WEI AI, M.D., PH.D., is an oncologist specializing in lymphoma and bone marrow transplant. Her research focuses on developing effective vaccine treatments and other novel therapeutics for lymphoma, including skin lymphoma. Dr. Ai is an assistant clinical professor in the UCSF Division of Hematology and Oncology.
  • SHAILENDER BHATIA, M.D., is an Assistant Professor in the Department of Medicine at University of Washington. He completed his fellowship training in Medical Oncology at the University of Washington/Fred Hutchinson Cancer Research Center. His research efforts are focused on clinical and translational research in skin cancers (melanoma and Merkel cell carcinoma).
  • ADIL DAUD, M.D., is widely recognized for his efforts in cancer clinical trials and he has pioneered several novel therapies for melanoma. He did his medical oncology fellowship training at Memorial Sloan Kettering Cancer Center in New York City and then moved to Moffitt Cancer Center, where he conducted the first human trial of DNA IL-12 with electroporation in patients with melanoma.
  • RICHARD HELLER, PH.D., Director, Frank Reidy Research Center for Bioelectrics, Old Dominion University, is developing in vivo delivery procedures for non-viral gene therapy. His approach utilizes pulsed electric fields to facilitate targeting and uptake of delivered molecules.
  • IACOB MATHIESEN, PH.D. has been a pioneer in the advancement of novel electroporation methods and devices for DNA delivery. He co-founded Inovio AS in 1999, a research and development company, which pursued advancements in the field of electroporation-based DNA delivery and was successful in securing pivotal patents, developing leading edge devices, and securing strategic partnerships.
  • PAUL NGHIEM, M.D., specializes in skin cancers, with a particular interest in optimizing the management of patients with Merkel cell carcinoma (MCC). He has cared for over 300 patients with MCC and has lectured and written about this rare and challenging disease. Dr. Nghiem conducts basic science research on cancer biology at the University of Washington and Fred Hutchinson Cancer Research Center in Seattle.
  • CHRISTIAN OTTENSMEIER, M.D., is one the UK’s leading researchers in cancer vaccines. He and his team are investigating how to stimulate the body’s own immune system to recognize and kill cancer cells. The technique could be used in future treatments for cancers such as lymphoma and myeloma but also solid cancers such as bowel, lung or prostate.
  • ALAIN ROOK, M.D. is an internationally recognized dermatologist and a leader in the research and development of novel therapies for cutaneous T-cell lymphoma (CTCL). As Director of the Cutaneous Lymphoma Program at the University of Pennsylvania he oversees one of the largest referral programs in the United States with more than 400 new CTCL referrals and nearly 2,000 total CTCL visits annually.
  • DAVID WEINER, PH.D. is a world-renowned leader in immunology as well as gene vaccines and therapy. As a pioneer in the field of DNA vaccines, he has over 300 peer-reviewed publications in scientific journals to his credit and publication in mainstream scientific journals such as Scientific American. Dr. Weiner has been selected by the Institute for Scientific Information as one of the top cited scientists in the world.

About OncoSec’s ElectroImmunotherapy and Electroporation Delivery

OncoSec’s ElectroImmunotherapy consists of a DNA-based cytokine delivered using electroporation. Consisting of a DNA plasmid (manufactured circles of DNA) coded to produce a specific cytokine such as IL-12, this DNA immunotherapeutic is injected into locally targeted tumors and surrounding tissue and followed by electroporation. This results in significant uptake of the agent by cells in this area of tissue. The DNA plasmid instructs these cells to “express” the protein it was designed to produce, such as IL-12. After the immune system detects the immunotherapeutic agent, it produces significant amounts of immune agents such as macrophages and killer T-cells that are able to kill cancerous cells.

Cytokine immunotherapeutics such as IL-12 have been directly injected in the form of proteins and have been shown to induce innate immune system responses capable of killing cancerous cells. Unfortunately they can also cause toxic side effects as the immune system perceives the proteins to be foreign. When DNA IL-12 is injected, the IL-12 produced by the body does not induce this unwanted immune response but has been shown to induce an immune response against cancer cells.

In these Phase II trials OncoSec will employ its in vivo electroporation device, or OncoSec Medical System (OMS), to enhance the potency of the DNA IL-12. The OMS consists of a pulse generator and handheld applicator with a sterile disposable array. The system delivers nano-second electrical pulses that increase cell membrane permeability, resulting in significant cellular uptake of the DNA plasmid and subsequent gene expression (i.e. production of the coded antigen). OMS can increase gene expression by 1000-fold and immune responses by 100 times or more compared to an un-enhanced delivery of a DNA plasmid.

About OncoSec Medical Inc.

OncoSec Medical Incorporated (OTC BB: ONCS.OB) is focused on designing, developing and commercializing innovative medical approaches to treat solid tumor cancers with unmet medical needs or where currently approved therapies are inadequate based on their efficacy level or side effect profile. The company’s therapies are based on the use of electroporation delivery in combination with an approved chemotherapeutic drug or a cytokine agent to treat solid tumors. More information is available at www.oncosec.com.

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This press release contains forward looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Any statements in this release that are not historical facts may be considered such “forward looking statements.” Forward looking statements are based on management’s current preliminary expectations and are subject to risks and uncertainties which may cause our results to differ materially and adversely from the statements contained herein. Some of the potential risks and uncertainties that could cause actual results to differ from those predicted include our ability to raise additional funding, our ability to acquire, develop or commercialize new products, uncertainties inherent in pre-clinical studies and clinical trials, unexpected new data, safety and technical issues, competition and market conditions. These and additional risks and uncertainties are more fully described in OncoSec’s filings with the Securities and Exchange Commission. Undue reliance should not be placed on forward looking statements which speak only as of the date they are made. OncoSec disclaims any obligation to update any forward looking statements to reflect new information, events or circumstances after the date they are made, or to reflect the occurrence of unanticipated events.

OncoSec Announces Leadership Team Appointments

Therapeutic oncology company moving into efficacy trials

SAN DIEGO, Ca, May 11, 2011 — OncoSec Medical Inc. (OTCBB: ONCS), a therapeutic oncology company developing innovative medical approaches to treat solid tumor cancers that have unmet medical needs, announced today the appointment of three members to its leadership team.Formed earlier this year, OncoSec expects to initiate Phase II clinical trials for its tumor-destroying, tissue-sparing ElectroOncology therapies before the end of this year.

OncoSec’s novel targeted tumor therapiesare designed to address the drawbacks of conventional therapies by being tissue sparing; providing potential functional, cosmetic and quality of life benefits; being less invasive and reducing side effects; and potentially reducing both treatment and post-treatment costs.Based on extensive past validating data from human studies, OncoSec expects to initiate advanced stage clinical studies for its ElectroImmunotherapy and ElectroChemotherapy programs by the end of 2011.

It is estimated that half of the 1.4 million cancers diagnosed each year in the United States are solid-tumor cancers. Cancers of the lung, prostate, colon, rectum or breast cancer are all solid tumor cancers. The National Institutes of Health estimated the annual cost of cancer to be $228.1 billion in 2008.

Today, Punit Dhillon, OncoSec’s co-founder, President and CEO, announced the following management appointments:

Dr. Michael Cross, Chief Business Officer

Michael Cross, PhD, a co-founder of OncoSec, will serve as Chief Business Officer. He will be responsible for business development, engineering operations, partnerships and fundraising, among other duties. Dr. Cross, who holds an MBA, has nearly two decades of life sciences venture capital and biotech industry experience. Prior to joining OncoSec, Dr. Cross was Vice President at GrowthWorks and Senior Vice President at Jovian Capital in Toronto. Previous to Jovian, Cross had lead operational responsibilities as COO of a public oncology company, Viventia Biotech, where he helped bring an anti-cancer antibody product into worldwide pivotal clinical trials.

Caryn Peterson, Vice President, Regulatory Affairs

Caryn Peterson brings to OncoSec more than 30 years of pharmaceutical industry experience in research and development, operations, and regulatory affairs. Prior to joining OncoSec, she led worldwide regulatory affairs for Syndax, a late-stage oncology company. Peterson also managed regulatory affairs at Ascenta Therapeutics and FeRx Inc., both oncology focused companies. She also worked in regulatory affairs at Amylin Pharmaceuticals, with a focus on first-in-class diabetes therapies. She is a founder and general partner of DSC-Associates, a pharmaceutical consulting group specializing in providing preclinical and clinical strategies to streamline product development.Ms. Peterson has authored several research publications and been a co-inventor on multiple patents.

Veronica Vallejo, CPA, Controller and Principal Financial Officer

Veronica Vallejo will serve as Controller and Principal Financial Officer. She has extensive experience in public accounting, most recently as a Senior Manager with Mayer Hoffman McCann P.C., a nationwide accounting firm.Ms. Vallejo has extensive experience in public company operations and all finance and accounting functions, including SEC reporting, compliance and internal controls.

These three leaders join Mr. Dhillon, co-founder, President and CEO, who has over 12 years of senior management experience in the biotech industry. He was recently VP Finance & Operations at Inovio Pharmaceuticals, Inc., where he played a pivotal role in raising over $125 million in funding. His operating and corporate finance experience includes product development, raising capital, merger and acquisition transactions and integration, partnering, clinical trials management, US and international regulatory oversight, and P&L and cash management. Mr. Dhillon also worked on numerous programs with the venture capital firm MDS Capital Corp., now Lumira Capital Corp.

About OncoSec Medical Inc.

OncoSec Medical Incorporated (OTC BB: ONCS.OB) is focused on designing, developing and commercializing innovative medical approaches to treat solid tumor cancers with unmet medical needs or where currently approved therapies are inadequate based on their efficacy level or side effect profile. The company’s therapies are based on the use of electroporation delivery in combination with an approved chemotherapeutic drug or a cytokine agent to treat solid tumors. More information is available at www.oncosec.com.

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This press release contains forward looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Any statements in this release that are not historical facts may be considered such “forward looking statements.” Forward looking statements are based on management’s current preliminary expectations and are subject to risks and uncertainties which may cause our results to differ materially and adversely from the statements contained herein. Some of the potential risks and uncertainties that could cause actual results to differ from those predicted include our ability to raise additional funding, our ability to acquire, develop or commercialize new products, uncertainties inherent in pre-clinical studies and clinical trials, unexpected new data, safety and technical issues, competition and market conditions. These and additional risks and uncertainties are more fully described in OncoSec’s filings with the Securities and Exchange Commission. Undue reliance should not be placed on forward looking statements which speak only as of the date they are made. OncoSec disclaims any obligation to update any forward looking statements to reflect new information, events or circumstances after the date they are made, or to reflect the occurrence of unanticipated events.

OncoSec Medical Licenses Non-DNA Vaccine Tumor Therapy Technology from Inovio Pharmaceuticals

OncoSec to develop and commercialize electrochemical and cytokine tumor therapy applications of electroporation technology

SAN DIEGO, CA, Mar. 15, 2011 — OncoSec Medical Inc. (OTC BB: ONCS.D), a developer of innovative and proprietary medical approaches to treat solid tumor cancers with unmet medical needs, announced today that it has signed an agreement with Inovio Pharmaceuticals, Inc. (NYSE Amex: INO) providing for the purchase by OncoSec of certain non-DNA vaccine technology and intellectual property relating to electroporation technology useful for electrochemical and cytokine based immune therapies for treating solid tumors. OncoSec will pay Inovio an undisclosed purchase price for the assigned assets and cash fees and a royalty on commercial product sales.

Dr. J. Joseph Kim, Inovio’s president and CEO, said: “As Inovio advances its leadership in the DNA vaccine field with several Phase II clinical studies for cervical dysplasia, leukemia, and hepatitis C virus therapies, we are pleased to enable third parties to commit their focus and resources to achieve the commercial potential of Inovio’s non-DNA vaccine assets. Prior clinical testing of our selective electrochemical tumor treatment and cytokine cancer therapies produced promising results and we are excited to monetize this electroporation asset for these applications and see its advancement by OncoSec. We wish the company every success in this endeavor.”

Mr. Punit Dhillon, OncoSec’s president and CEO, said: “We are excited to conclude this agreement with Inovio to acquire this promising technology for locally targeted cancer treatments, which have previously achieved important clinical outcomes, and immediately begin the implementation of our clinical development and commercialization plan. There are millions of people in the US alone who face detrimental cosmetic, functional and pain outcomes resulting from the invasive treatments used today for various skin and other cancers – in addition, the nature of current treatments results in high treatment and post-treatment costs to the medical system.”

The electroporation technology being sold and licensed to OncoSec is based on Inovio’s industry-leading electroporation technology platform that, in addition to DNA vaccines and immune therapeutics, can also be used to efficiently deliver a chemotherapeutic or cytokine agent for the treatment of cancer. When these chemotherapeutic or cytokine agents are injected into a selected treatment area such as a tumor and the predominantly healthy tissue in the margin surrounding a tumor, they have been shown to selectively and quickly destroy the tumor and cancer cells in the tumor margin. The chemotherapeutic agent acts by directly killing cancerous cells at the delivery site. Cytokine agents act by inducing broad, non-antigen specific immune responses that have been shown to kill cancerous cells. These therapies enable heightened concentrations of medicine to be directed to the cancer while reducing overall dosage and moderating or eliminating side effects associated with systemically-applied therapeutic approaches. This optimized delivery is enabled by Inovio’s proprietary electroporation process, which locally applies brief controlled electrical pulses to cells to temporarily and reversibly increase permeability of the cell membranes in selected tissue and dramatically increase cellular uptake of the previously injected agent as seen in previous animal studies and earlier human clinical trials.

About OncoSec Medical Inc.

OncoSec (OTC BB: ONCS.D), based in San Diego, California, designs, develops and commercializes innovative and proprietary medical approaches to treat solid tumor cancers with unmet medical needs or where currently approved therapies are inadequate based on their efficacy level or side effect profile. The company’s therapies are based on the use of electroporation delivery in combination with an approved chemotherapeutic drug or a cytokine agent to treat solid tumors. More information is available at www.oncosec.com.

About Inovio Pharmaceuticals, Inc.

Inovio is developing a new generation of vaccines, called DNA vaccines, to treat and prevent cancers and infectious diseases. These SynCon™ vaccines are designed to provide broad cross-strain protection against known as well as newly emergent strains of pathogens such as influenza. These vaccines, in combination with Inovio’s proprietary electroporation delivery devices, have been shown to be safe and generate significant immune responses. Inovio’s clinical programs include three separate programs in Phase II clinical studies, including VGX-3100 for treating cervical dysplasia and cancer. Other Inovio clinical programs include those for avian flu (preventive) and HIV vaccines (both preventive and therapeutic). Inovio is developing universal influenza and other vaccines in collaboration with scientists from the University of Pennsylvania. Other partners and collaborators include Merck, ChronTech, National Cancer Institute, U.S. Military HIV Research Program, NIH, HIV Vaccines Trial Network, University of Southampton, and PATH Malaria Vaccine Initiative. More information is available at www.inovio.com.

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This press release contains forward looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Any statements in this release that are not historical facts may be considered such “forward looking statements.” Forward looking statements are based on management’s current preliminary expectations and are subject to risks and uncertainties which may cause our results to differ materially and adversely from the statements contained herein. Some of the potential risks and uncertainties that could cause actual results to differ from those predicted include our ability to raise additional funding, uncertainties inherent in pre-clinical studies and clinical trials, unexpected new data, safety and technical issues, competition and market conditions. These and additional risks and uncertainties are more fully described in OncoSec’s filings with the Securities and Exchange Commission. Undue reliance should not be placed on forward looking statements which speak only as of the date they are made. OncoSec disclaims any obligation to update any forward looking statements to reflect new information, events or circumstances after the date they are made, or to reflect the occurrence of unanticipated events.