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OncoSec Releases Devices For Use In Clinical Trials

SAN DIEGO, CA, October 4, 2011 — OncoSec Medical Incorporated (OTCBB: ONCS), which is developing its advanced-stage OMS ElectroOncology™ therapies to treat solid tumor cancers, announced today that the OncoSec Medical System (OMS) devices have been qualified and released and are now ready for shipment to clinical sites in time for the upcoming OMS ElectroImmunotherapy™ clinical trials.

In March 2011 OncoSec acquired the rights to an electroporation delivery technology platform that can be used to efficiently deliver a chemotherapeutic or DNA-based cytokine agent for the treatment of solid tumors, which OncoSec has branded as the OncoSec Medical System (OMS). Since then, projects were initiated to establish engineering and manufacturing capabilities, as well as, transfer and update regulatory, design and manufacturing documentation, including implementing a new quality assurance system. Over the course of five months a manufacturing plan was executed to ensure that the devices acquired by OncoSec were safe and ready for use in clinical trials. The company now has inventory of OMS investigational devices adequate to support known and anticipated clinical study requirements well into 2013. OncoSec’s current infrastructure and facility is designed to support manufacturing, assembly, testing, technical and regulatory support for multiple clinical trials in compliance with FDA and quality systems regulations. The extent of OncoSec manufacturing operations allow the company to build and maintain the current device supply to support on-going and future clinical trials, scale up production as needed as well as design and develop a next generation OMS electroporation system. The company utilizes contract manufacturers for key operations, such as clean room assembly and sterilization, which are not presently economically conducted in-house.

“Since acquiring the technology our team has worked diligently to test, and re-test, the OMS device to ensure that it is safe and ready for in-human use, as well as, manufacture new applicators and applicator handles for the OMS ElectroImmunotherapy™ clinical trials. I am delighted to report that they are now ready for shipment to the clinical sites,” said, Dr. Michael Cross, OncoSec’s Chief Business Officer, “This milestone also highlights the fact that OncoSec now has the in-house capabilities to build, maintain and develop our own devices, while still having the flexibility to outsource specific manufacturing activities, where required, thereby allowing OncoSec to hold strict control over manufacturing costs.”

OncoSec intends to initiate three Phase II clinical trials using the OMS ElectroImmunotherapy™ treatment approach for melanoma, Merkel cell carcinoma and cutaneous T-cell lymphoma by the end of October 2011. “The release of these devices is an integral step in our development plan. With the achievement of this milestone, we continue to meet the goals set out by our corporate strategy, and expect to move toward validating the data seen in the Phase I study in our upcoming clinical trials.,” said Punit Dhillon, President and CEO.

About OncoSec Medical Inc.

OncoSec Medical Incorporated (OTCBB: ONCS) develops novel OMS ElectroOncology therapies that combine its proprietary electroporation delivery technology with a chemotherapeutic or novel DNA-based immunotherapeutics. Targeted local delivery of these agents is designed to achieve selective destruction of cancerous tumors while sparing healthy normal tissue, resulting in improved functional, cosmetic and quality of life outcomes. These therapies have achieved validating safety and efficacy data in early and late stage clinical studies of over 400 cancer patients. OncoSec’s clinical programs include three Phase II clinical trials. More information is available at www.oncosec.com.

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This press release contains forward looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Any statements in this release that are not historical facts may be considered such “forward looking statements.” Forward looking statements are based on management’s current preliminary expectations and are subject to risks and uncertainties which may cause our results to differ materially and adversely from the statements contained herein. Some of the potential risks and uncertainties that could cause actual results to differ from those predicted include our ability to raise additional funding, our ability to acquire, develop or commercialize new products, uncertainties inherent in pre-clinical studies and clinical trials, unexpected new data, safety and technical issues, competition and market conditions. These and additional risks and uncertainties are more fully described in OncoSec’s filings with the Securities and Exchange Commission. Undue reliance should not be placed on forward looking statements which speak only as of the date they are made. OncoSec disclaims any obligation to update any forward looking statements to reflect new information, events or circumstances after the date they are made, or to reflect the occurrence of unanticipated events.

OncoSec ElectroImmunotherapy Shows Systemic Effects of Metastatic Melanoma Tumor in More than 50% of Patients

Data from previous Phase I study identifies that presence of novel antigens plus DNA IL-12 delivered using electroporation achieves stabilization and regression of treated and distant untreated melanoma tumors

SAN DIEGO, CA, June 7, 2011 — OncoSec Medical Incorporated (OTCBB: ONCS), which is developing its advanced-stage ElectroOncology therapies to treat solid tumor cancers, announced today that additional evaluation of a previous Phase I trial provided further evidence that a DNA plasmid encoded to produce IL-12 delivered by electroporation into melanoma lesions induces responses to known and novel antigens, resulting in regression of local treated lesions as well as distant untreated lesions. The results were presented by Dr. Adil Daud, principal investigator of the study, at the ASCO 2011 Annual Meeting.

In this Phase I trial, the experimental regimen was safe and well tolerated, with minimal systemic toxicity. Local treated lesions were biopsied and showed that 76% of all samples had at least 20% necrosis of the tumor, with 34% of those lesions showing 100% necrosis (clearance of the tumor). Furthermore, patients with additional tumors beyond the treated tumor were followed to determine regression of distant untreated lesions. Results demonstrated that 10 (53%) of 19 patients with distant untreated lesions showed at least stable disease or objective (partial or complete) regression. In addition, 15% of these patients demonstrated 100% clearance of distant, untreated metastatic melanoma tumors; by comparison, only 0.25% of such tumors would normally be expected to clear on their own if left untreated. The observed tumor regression of untreated lesions suggested a systemic immune response to the localized treatment. The data demonstrated a dose-dependent increase in intratumoral IL-12 protein expression and concomitant increases in intratumoral IFN-gamma. In addition, this study showed that electroporated tumors contained CD4+ and CD8+ lymphocytic infiltrates in the treated lesions, further validating the ability of DNA IL-12 to up-regulate adaptive and innate immunity.

Following this Phase I study, the researchers conducted additional analysis into the ability of DNA IL-12 to induce a systemic immune response against distant metastatic lesions and more importantly to potentially identify blood markers that can be used to predict if a specific sub-set of patients is more likely to respond to DNA IL-12. Evaluable patients were categorized by tumor response (complete, partial response, stable disease or disease progression) and the researchers analyzed blood samples obtained at weeks 1, 4 and 6. Among numerous antigens tested and identified, two candidates, namely epidermally-localized protein (4.2-fold, p = 0.008) and a testis-restricted antigen (3.0-fold, p = 0.037), were present in subjects who displayed a significant differential in tumor response versus those that were non-responders. These results indicate that blood markers may exist that can predict whether patients will respond to treatment with DNA IL-12 with electroporation, further adding to the selective potential of this treatment.

Dr. Adil Daud, Clinical Professor of Medicine at the University of California, San Francisco, who led the exploratory study, said, “This first-in-man study demonstrated that local intratumoral electroporation of DNA IL-12 in melanoma induces systemic immune responses that can stabilize or cause regression of not only local treated but also distant untreated metastatic melanoma tumors. We are also pleased with this new analysis indicating that measurable blood markers may be useful in selecting patients more likely to respond to this treatment. These results provide significant encouragement that DNA-IL12 delivered with electroporation may represent an important new treatment against challenging cancers such as melanoma.”

Punit Dhillon, OncoSec’s President and CEO, said, “Melanoma is an aggressive skin cancer, and metastatic melanoma is generally lethal. Just stabilizing this disease is an accomplishment, but we are very enthusiastic about the results of this Phase I study showing regression of treated and untreated tumors, as well as the insights into potential new markers. We look forward to launching OncoSec’s planned three Phase II skin cancer trials this summer. Our goal is to further validate these results and show the breakthrough nature of this tissue-sparing, tumor killing drug/device cancer therapy.”

This data relates to OncoSec’s ElectroImmunotherapy using a DNA plasmid coding for IL-12 that is delivered using electroporation. Electroporation enables significant cellular uptake of the DNA IL-12, which then instructs the cells to produce the protein IL-12. IL-12 stimulates the release of cytotoxic T-cells, natural killer (NK) cells, and IFN-gamma, which in conjunction up-regulate the production of CD4+ and CD8+ lymphocytic infiltrates, resulting in an immuno-reaction against cancers that leads to cancer cell death.

OncoSec has announced that it will initiate three Phase II clinical trials in the next several months to assess its ElectroImmunotherapy technology in patients with melanoma, Merkel cell carcinoma and cutaneous T-cell lymphoma. If OncoSec’s Phase II trials further validate the initial Phase I evidence, the DNA-based IL-12 ElectroImmunotherapy platform would represent an important advancement in the treatment of both local and metastatic cancers.

About Melanoma

The incidence of many common cancers is falling, but the incidence of melanoma continues to rise at a rate faster than that of any of the seven most common cancers. Between 1992 and 2004, melanoma incidence increased 45 percent, or 3.1 percent annually. An estimated 68,000 new cases of melanoma were diagnosed in the U.S. in 2010 – with nearly 8,700 resulting in death. Approximately 75 percent of skin cancer deaths are from melanoma. In 2004, the most recent figures available, the total direct medical cost associated with the treatment of skin cancer in the U.S. was $1.5 billion. Currently there are few treatment options for metastatic melanoma because of the aggressive nature of the disease. Current treatment approaches are associated with high morbidity and only marginal improvements in overall survival.

About OncoSec Medical Inc.

Oncosec Medical (OTCBB: ONCS) develops novel ElectroOncology therapies that combine its proprietary electroporation delivery technology with a chemotherapeutic or novel DNA-based immunotherapeutics. Targeted local delivery of these agents is designed to achieve selective destruction of cancerous tumors while sparing healthy normal tissue, resulting in improved functional, cosmetic and quality of life outcomes. These therapies have achieved validating safety and efficacy data in early and late stage clinical studies of over 400 cancer patients. OncoSec’s clinical programs include three Phase II clinical trials. More information is available at www.oncosec.com.

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This press release contains forward looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Any statements in this release that are not historical facts may be considered such “forward looking statements.” Forward looking statements are based on management’s current preliminary expectations and are subject to risks and uncertainties which may cause our results to differ materially and adversely from the statements contained herein. Some of the potential risks and uncertainties that could cause actual results to differ from those predicted include our ability to raise additional funding, our ability to acquire, develop or commercialize new products, uncertainties inherent in pre-clinical studies and clinical trials, unexpected new data, safety and technical issues, competition and market conditions. These and additional risks and uncertainties are more fully described in OncoSec’s filings with the Securities and Exchange Commission. Undue reliance should not be placed on forward looking statements which speak only as of the date they are made. OncoSec disclaims any obligation to update any forward looking statements to reflect new information, events or circumstances after the date they are made, or to reflect the occurrence of unanticipated events.

OncoSec Announces Leadership Team Appointments

Therapeutic oncology company moving into efficacy trials

SAN DIEGO, Ca, May 11, 2011 — OncoSec Medical Inc. (OTCBB: ONCS), a therapeutic oncology company developing innovative medical approaches to treat solid tumor cancers that have unmet medical needs, announced today the appointment of three members to its leadership team.Formed earlier this year, OncoSec expects to initiate Phase II clinical trials for its tumor-destroying, tissue-sparing ElectroOncology therapies before the end of this year.

OncoSec’s novel targeted tumor therapiesare designed to address the drawbacks of conventional therapies by being tissue sparing; providing potential functional, cosmetic and quality of life benefits; being less invasive and reducing side effects; and potentially reducing both treatment and post-treatment costs.Based on extensive past validating data from human studies, OncoSec expects to initiate advanced stage clinical studies for its ElectroImmunotherapy and ElectroChemotherapy programs by the end of 2011.

It is estimated that half of the 1.4 million cancers diagnosed each year in the United States are solid-tumor cancers. Cancers of the lung, prostate, colon, rectum or breast cancer are all solid tumor cancers. The National Institutes of Health estimated the annual cost of cancer to be $228.1 billion in 2008.

Today, Punit Dhillon, OncoSec’s co-founder, President and CEO, announced the following management appointments:

Dr. Michael Cross, Chief Business Officer

Michael Cross, PhD, a co-founder of OncoSec, will serve as Chief Business Officer. He will be responsible for business development, engineering operations, partnerships and fundraising, among other duties. Dr. Cross, who holds an MBA, has nearly two decades of life sciences venture capital and biotech industry experience. Prior to joining OncoSec, Dr. Cross was Vice President at GrowthWorks and Senior Vice President at Jovian Capital in Toronto. Previous to Jovian, Cross had lead operational responsibilities as COO of a public oncology company, Viventia Biotech, where he helped bring an anti-cancer antibody product into worldwide pivotal clinical trials.

Caryn Peterson, Vice President, Regulatory Affairs

Caryn Peterson brings to OncoSec more than 30 years of pharmaceutical industry experience in research and development, operations, and regulatory affairs. Prior to joining OncoSec, she led worldwide regulatory affairs for Syndax, a late-stage oncology company. Peterson also managed regulatory affairs at Ascenta Therapeutics and FeRx Inc., both oncology focused companies. She also worked in regulatory affairs at Amylin Pharmaceuticals, with a focus on first-in-class diabetes therapies. She is a founder and general partner of DSC-Associates, a pharmaceutical consulting group specializing in providing preclinical and clinical strategies to streamline product development.Ms. Peterson has authored several research publications and been a co-inventor on multiple patents.

Veronica Vallejo, CPA, Controller and Principal Financial Officer

Veronica Vallejo will serve as Controller and Principal Financial Officer. She has extensive experience in public accounting, most recently as a Senior Manager with Mayer Hoffman McCann P.C., a nationwide accounting firm.Ms. Vallejo has extensive experience in public company operations and all finance and accounting functions, including SEC reporting, compliance and internal controls.

These three leaders join Mr. Dhillon, co-founder, President and CEO, who has over 12 years of senior management experience in the biotech industry. He was recently VP Finance & Operations at Inovio Pharmaceuticals, Inc., where he played a pivotal role in raising over $125 million in funding. His operating and corporate finance experience includes product development, raising capital, merger and acquisition transactions and integration, partnering, clinical trials management, US and international regulatory oversight, and P&L and cash management. Mr. Dhillon also worked on numerous programs with the venture capital firm MDS Capital Corp., now Lumira Capital Corp.

About OncoSec Medical Inc.

OncoSec Medical Incorporated (OTC BB: ONCS.OB) is focused on designing, developing and commercializing innovative medical approaches to treat solid tumor cancers with unmet medical needs or where currently approved therapies are inadequate based on their efficacy level or side effect profile. The company’s therapies are based on the use of electroporation delivery in combination with an approved chemotherapeutic drug or a cytokine agent to treat solid tumors. More information is available at www.oncosec.com.

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This press release contains forward looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Any statements in this release that are not historical facts may be considered such “forward looking statements.” Forward looking statements are based on management’s current preliminary expectations and are subject to risks and uncertainties which may cause our results to differ materially and adversely from the statements contained herein. Some of the potential risks and uncertainties that could cause actual results to differ from those predicted include our ability to raise additional funding, our ability to acquire, develop or commercialize new products, uncertainties inherent in pre-clinical studies and clinical trials, unexpected new data, safety and technical issues, competition and market conditions. These and additional risks and uncertainties are more fully described in OncoSec’s filings with the Securities and Exchange Commission. Undue reliance should not be placed on forward looking statements which speak only as of the date they are made. OncoSec disclaims any obligation to update any forward looking statements to reflect new information, events or circumstances after the date they are made, or to reflect the occurrence of unanticipated events.