Head and Neck Cancer

Head and Neck Cancer

 

The point at which cancer is discovered in the body can make a large impact on successful treatment. However, different types of cancer can be discovered much more easily than others. While many types of cancers form inside the body and are much harder to detect – with the naked eye – there are some that start on the skin or exterior of the body and are easy to see. Having regular check-ups – and being screened for cancer, at the first sign of a problem – will make all the difference.

Data Presented at the 8th International Conference on Head and Neck Cancer Demonstrate Equivalent Disease Control and Survival, and Improved Functional Outcomes and Quality of Life Compared to Surgery

 

SAN DIEGO, CA — July 23, 2012 — OncoSec Medical Inc. (OTCBB:ONCS), a company developing the advanced-stage OncoSec Medical System (OMS) ElectroOncology therapies to treat solid tumors, announced data from an interim analysis of two randomized Phase III clinical trials, HNBE-01 and HNBE-02, using electrochemotherapy to treat locally recurrent and second primary squamous cell carcinoma of the head and neck (SCCHN). The data are being presented July 22-24 at the 8th International Conference on Head and Neck Cancer in Toronto, Canada. A link to the abstract can be found here.

In these studies, electrochemotherapy was compared against surgery for quality of life, safety, survival and local control at eight months, where local control is defined as destruction of the treated tumor without evidence of reappearance of the tumor at the treatment site. The data show OMS ElectroChemotherapy achieved the primary endpoint of preserving quality of life compared to surgery, and appears to be safe and comparable to surgery in achieving control in locally recurrent or second primary SCCHN. This therapy represents a viable alternative to potentially major surgical interventions for this patient population, where recurrent tumors in SCCHN usually have a poor prognosis with a local control rate of 40-50 percent and frequently associated loss of organ function.

Paul Goldfarb, M.D., Consulting Medical Director of OncoSec overseeing the Phase III studies, said, “Despite the early termination of this study, delayed interim analysis of these data clearly demonstrated there was equivalence in safety, local control at eight months and survival between electrochemotherapy and surgery, with a benefit of quality of life and function for patients who received electrochemotherapy.”

OncoSec is evaluating the regulatory strategy alternatives for the most optimal path to market clearance based on the available Phase III and previously announced Phase IV data. Concurrently, the company is seeking partnering opportunities as it begins to approach the FDA and other regulatory bodies with product registration plans.

Punit Dhillon, President and CEO of OncoSec, said, “Interim analysis of these two Phase III studies, and the recently released data from the Phase IV study carried out in Europe, has demonstrated that the primary endpoint of maintaining quality of life was achieved. In addition, OMS ElectroChemotherapy appears to provide a potentially important treatment alternative to surgery that may address hard-to-treat tumors where there exists a particular need to preserve function and quality of life. These data strongly support our partnering efforts for the OMS ElectroChemotherapy program.”

 

Study Design

HNBE-01 and HNBE-02 were designed as two open-label pivotal studies in which 214 patients with locally recurrent or second primary tumors, anterior and posterior to the tonsillar pillar, respectively, and amenable to surgical resection, were randomized 1:1 between surgery (control group) and electrochemotherapy (treatment group). The primary endpoint for these studies was quality of life, as measured by the Performance Status Scale for Head and Neck Cancer (PSSHN). Secondary endpoints were safety, local control at eight months and survival. For the treatment group, patients received local injection of bleomycin followed by electroporation. Radiation or neck dissection was permitted when warranted.

These studies were initiated in 2004 and subsequently closed in 2007, and were conducted at 22 sites in the United States, Canada, Eastern and Western Europe. Of the 214 enrolled subjects, 130 were randomized into HNBE-01 and 84 into HNBE-02. This study was terminated at the interim point following an independent data monitoring committee review; however, all treated patients were followed for up to two years to evaluate safety and efficacy. At the time of this analysis, there were a total of 98 evaluable subjects, 58 from HNBE-01 and 40 from HNBE-02.

 

Efficacy and Quality of Life

There were no statistically significant differences between time to death or local control rate at eight months between the control and experimental groups for HNBE-01 or HNBE-02 or the combination of both studies. Median time to death was statistically indistinguishable between surgery at 209 days versus 231 days for electrochemotherapy (p=0.55). Local tumor control at eight months was achieved in 92% of control group patients versus 90% of electrochemotherapy patients.

Quality of life was evaluated using the performance status scale for head and neck cancer patients (PSSHN), a functional outcome measurement assessing the ability to swallow, normalcy of diet and ability to eat in public. Assessment of quality of life by the PSSHN score showed a mean score of 269 at baseline versus 248 at eight months for the control group (p=0.036) versus 257 at baseline versus 249 at eight months for the electrochemotherapy group (p=0.59). While the scores in the electrochemotherapy group remained relatively unchanged at eight months, the surgery group in each trial showed a statistically significant decrease in overall function. The preservation of function and quality of life in the treatment group may be the result of the ability of OMS ElectroChemotherapy to spare surrounding vital tissue and reduce removal or destruction of additional tissue.

 

Safety

Early termination of these studies was recommended by the data monitoring committee following an interim review of safety data at the midway point of enrollment for HNBE-01 and HNBE-02. The interim analysis of long-term follow-up data at up to two years indicates there were no safety issues relating to electrochemotherapy, as reflected by the statistically significant equivalence between the groups in time to death. The most frequently reported adverse events, which were pain, nausea and local edema, were also equivalent for both groups of patients. There were no adverse experiences related to device performance observed among the 98 patients with squamous cell carcinoma of the head and neck who were evaluated, and no procedures were stopped as a result of device malfunction.

 

About OMS ElectroChemotherapy (Formerly SECTA)

On May 29, 2007 the Data Monitoring Committee (DMC) overseeing both the HNBE-01 and HNBE-02 studies recommended that enrollment of both studies be terminated, citing concerns regarding efficacy and safety, including mortality rates and enrollment futility. In the review by the DMC of interim data, the totality of the data indicated an unfavorable benefit to risk profile for the ElectroChemotherapy treatment arm relative to the surgery arm (control arm). As a result, the DMC suggested that the studies be stopped and no further subject enrollment be continued. Based on this recommendation, both studies were halted. The treated patients were followed up to two years to further evaluate safety and efficacy, as per protocol, but no additional data analysis was performed until recently by OncoSec.

Upon OncoSec’s acquisition of these programs and other assets in 2011, OncoSec conducted a complete analysis of the data. This analysis indicated that there were no statistically significant differences between time to death or duration of local control between the control or ElectroChemotherapy experimental arms in either the HNBE-01 or HNBE-02 trials, or the combined groups across studies. Furthermore, none of the other parameters examined, including demographics, time since original diagnosis, prior therapies or tumor stage, showed any significant statistical difference between these parameters. The most frequent side effects were pain 35.4% for patients undergoing surgery and 46% for those treated with electrochemotherapy (all grades). Other items raised by the DMC were also evaluated and the Company is confident these can be, or have already been, addressed.

Phase IV Study Demonstrates Local Tumor Control in 94% of Primary and 57% of Recurrent Tumors and Enhanced Quality of Life in Patients Treated with OMS ElectroChemotherapy

SAN DIEGO, CA, April 23, 2012 — OncoSec Medical Inc. (OTCBB:ONCS), which is developing its advanced-stage OncoSec Medical System (OMS) ElectroOncology therapies to treat solid tumors, today announced positive interim analysis of data from 81 subjects in a Phase IV study of primary and locally recurrent squamous cell carcinoma of the head and neck (HNSCC) treated with OMS ElectroChemotherapy in Europe. The study demonstrated the therapy’s ability to provide local tumor control and quality of life outcomes that compare favorably to standard outcomes associated with surgery. These results were presented at the 5th European Conference on Head and Neck Oncology in Poznan, Poland on Friday, April 20, 2012.

The primary goal of this phase IV head and neck cancer study was to assess the ability of the OMS ElectroChemotherapy to control growth or recurrence of the cancer eight months following treatment, equivalent to surgery as compared to historical controls, with respect to primary (new) tumors and locally recurrent tumors. In this interim analysis, local tumor control was achieved in 46/49 (94%) primary tumors and 12/21 (57%) recurrent tumors. This meant that there was no recurrence of the tumors during the monitoring period. These were excellent results that were on par with the expected outcomes of surgery. Furthermore, evaluation of safety using the OMS ElectroChemotherapy for this patient population demonstrated that the treatment was safe and well-tolerated with no grade three or higher adverse events related to treatment reported during this study.

In addition, the secondary endpoint of preservation of organ function and appearance using validated quality of life instruments demonstrated a positive outcome. The functional outcome measurement to evaluate quality of life assesses the ability to swallow, normalcy of diet, and ability to eat in public and is often assessed by the Performance Status Scale for Head and Neck cancer (PSSHN); general quality of life was assessed by the European Organization for Research and Treatment of Cancer Core QOL questionnaire (EORTC QLQ). Treated patients showed a mean overall score of 264 at baseline vs. 249 at eight months (p=0.3412), indicating no significant difference in quality of life following treatment with OMS ElectroChemotherapy. This is an excellent outcome; if the patient had been treated with surgery, the expectation and historical experience would result in a greater degradation of function and quality of life for these patients as determined by the PSSHN and EORTC QLQ scores. Therefore, treatment with OMS ElectroChemotherapy provided a significant benefit in maintaining quality of life while achieving an equivalent local control compared to surgery. Additional secondary endpoints for this study included evaluation of pharmacoeconomic factors (hospital costs, extent of medical interventions, and medication use) as well as clinical performance of the OncoSec Medical System and applicator. The conclusions regarding these endpoints were positive and will be reviewed in a final publication.

“There is a significant unmet clinical need for an alternative to surgery that selectively destroys cancer cells without harming normal healthy tissue,” said Dr. Paul Goldfarb, medical director of OncoSec and principal investigator of this study. “This therapy provides patients who would typically be subjected to disfiguring surgery with potentially improved treatment outcomes.”

Punit Dhillon, President and CEO, said, “Our OMS ElectroChemotherapy treatment provided safe and clinically beneficial outcomes for patients while maintaining quality of life. We strongly believe in the clinical relevance of the OMS ElectroChemotherapy program and believe these results will help prospective partners to better define the broad applicability and market opportunity for this novel treatment.”

This Phase IV pre-marketing study was conducted in 11 European clinical centers of excellence with institutional review board and competent authority approval and carried out under standard good clinical practices using OncoSec’s OMS ElectroChemotherapy treatment platform for primary and recurrent head and neck cancer.

About Head and Neck Cancer

Head and neck cancers are difficult to treat because of the damage to adjacent healthy tissue that occurs during surgical resection. Nevertheless, surgery is often the first treatment approach for a primary or first occurrence of a head and neck cancer if its size and location is amenable to this approach. Treatment may also involve radiation therapy where the tumor is either more difficult to access or complete removal is questionable. The recurrence rate of primary head and neck cancer following surgery has been reported to be as high as 50% depending on the size and location of the tumor using conventional therapy. There is consequently an urgent need for a treatment alternative with the ability to improve local tumor control, thereby reducing the rate of recurrence and improving survival. In addition, many patients treated with surgery and/ or radiation will experience problems associated with loss of function, such as swallowing and speech, and cosmetic disfigurement, significantly impacting quality of life for these patients. If a recurrence occurs, treatment may again involve surgery, radiation and/or chemotherapy. At this point, the goal of local tumor control is to maintain quality of life, and potentially salvage and cure the patient. The challenge is to achieve these goals while minimizing the injury to adjacent healthy tissue and maintaining quality of life and functional outcomes. Each year, there are approximately 150,000 new cases of head and neck cancer in Europe, resulting in 65,000 deaths. Worldwide, approximately 560,000 cases of head and neck cancer are diagnosed, and 300,000 patients are expected to die annually.

About ElectroChemotherapy

OncoSec’s ElectroChemotherapy enables local application of a chemotherapeutic agent, bleomycin, directly into a tumor and the healthy margin of tissue surrounding the tumor and selectively kills cancerous cells. As opposed to surgery, this therapeutic approach can avoid removal of healthy tissue, providing beneficial appearance, organ function and quality of life outcomes.

About OncoSec Medical Inc.

OncoSec Medical Incorporated (OTCBB: ONCS) develops novel OMS ElectroOncology therapies that combine its proprietary electroporation delivery technology with a chemotherapeutic or novel DNA-based immunotherapeutics. Targeted local delivery of these agents is designed to achieve selective destruction of cancerous tumors while sparing healthy normal tissue, resulting in improved functional, cosmetic and quality of life outcomes. These therapieshave achieved validating safety and efficacy data in early and late stage clinical studies of over 400 cancer patients. OncoSec’s clinical programs include three Phase II clinical trials for OMS ElectroImmunotherapy. More information is available at www.oncosec.com. Additional information may also be found at OncoSec’s Facebook , Twitter, and LinkedIn sites.

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This press release contains forward looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Any statements in this release that are not historical facts may be considered such “forward looking statements.” Forward looking statements are based on management’s current preliminary expectations and are subject to risks and uncertainties which may cause ourresults to differ materially and adversely from the statements contained herein. Some of the potential risks and uncertainties that could cause actual results to differ from those predicted include our ability to raise additional funding, our ability to acquire, develop or commercialize new products, uncertainties inherent in pre-clinical studies and clinical trials, unexpected new data, safety and technical issues, competition and market conditions. These and additional risks and uncertainties are more fully described in OncoSec’s filings with the Securities and Exchange Commission. Undue reliance should not be placed on forward looking statements which speak only as of the date they are made. OncoSec disclaims any obligation to update any forward looking statements to reflect new information, events or circumstances after the date they are made, or to reflect the occurrence of unanticipated events.

New Analysis of Phase III and IV Head & Neck Cancer Results

SAN DIEGO, CA, March 22, 2012 — OncoSec Medical Incorporated. (OTCBB:ONCS), which is developing its advanced-stage OncoSec Medical System(OMS) ElectroOncology therapies to treat solid tumor cancers, today announced that the company has been selected to present data from its Phase III and IV head and neck cancer studies at two upcoming conferences. Data from the Phase IV study carried out in Europe has been selected for a poster session and special oral presentation at the 5th European Conference on Head and Neck Oncology. In addition, data from the Phase III study carried out in the United States has been selected for a poster presentation at the 8th International Head and Neck Cancer Conference.

OncoSec’s most advanced stage treatment platform, OMS ElectroChemotherapy, is a targeted ablation therapy, which utilizes the OMS to locally deliver bleomcyin to the tumor. This treatment platform preferentially kills targeted cancer cells while sparing surrounding normal healthy tissue. OMS ElectroChemotherapy has been developed up to Phase III clinical trials in the United States for the treatment of recurrent head and neck cancer and in Phase I/II for the treatment of recurrent breast cancer. In addition, Phase IV pre-marketing studies to support the commercialization of the OMS system in Europe were also performed for the treatment of primary and recurrent head and neck cancers and cutaneous skin cancers.

“Since acquiring the OMS ElectroChemotherapy assets in March 2011, we have been working diligently to compile and analyze data from the Phase III and IV studies carried out in the United States and Europe. We are excited that we will now have the opportunity to share this data with the public in the coming months,” said Punit Dhillon, President and CEO. “With this data, we expect to finalize our clinical development plan and move forward with commercializing the OMS ElectroChemotherapy platform with a partner, either regionally or globally.”

The Phase IV head and neck cancer results, carried out in Europe, will be presented at:
The 5th European Conference on Head and Neck Oncology
Poznan, Poland
April 18-21, 2012

Special Poster Session and Presentation
“Interim analysis of an open labeled, single arm multicenter study of electrochemotherapy in recurrent head and neck cancer”

The 8th International Head and Neck Cancer Conference
Toronto Convention Center
Toronto, Canada
July 21-25, 2012

Poster Session
“Interim analysis of two randomized Phase 3 trials comparing electrochemotherapy to surgery in recurrent head and neck cancer”

About OMS ElectroChemotherapy

Through its asset acquisition, OncoSec has accumulated a significant database of clinical data in a variety of tumor types using the OMS ElectroChemotherapy therapeutic approach. To date OMS ElectroChemotherapy has been tested in several clinical trials ranging from Phase I through Phase IV conducted in 13 countries across over 50 sites. Human data has been collected in over 400 patients with cancers ranging from basal and squamous cell carcinomas, melanoma, adenocarcinoma, Kaposi’s sarcoma, pancreatic, hepatic, oral, and head and neck cancers. OMS ElectroChemotherapy utilizes electroporation to locally deliver the chemotherapeutic drug bleomycin to treat solid tumors. A distinctive feature of the OMS ElectroChemotherapy treatment platform is both the preservation of healthy tissue and killing of cancerous cells in the lesion and at the margins of the tumor. It is anticipated that the system may therefore afford advantages over surgery in preserving function and improving the quality of life for cancer patients who would otherwise face significant morbidity associated with cancer surgery or other treatment modalities.

About Head and Neck Cancer

Most head and neck cancers are found in people over age 40. Men are two to three times more likely than women to have head and neck cancer,although rates in women have been rising along with their growing use of tobacco and alcohol. The number of new cases of head and neck cancers in the United States was 70,490 in 2008, accounting for about 3% of adult malignancies and the worldwide incidence exceeds half a million cases annually. It is estimated that approximately $3.1 billion is spent in the United States each year on treatment for head and neck cancers. Head and neck cancers encompass a diverse group of uncommon tumors that frequently are aggressive in their biologic behavior. Moreover, patients with a head and neck cancer often develop a second primary tumor, in part secondary to common risk factors. In North America and Europe, the tumors usually arise from the oral cavity, oropharynx, or larynx, whereas nasopharyngeal cancer is more common in the Mediterranean countries and in the Far East. In Southeast China and Taiwan, head and neckcancer, specifically nasopharyngeal cancer is the most common cause of death in young men.

About OncoSec Medical Inc.

OncoSec Medical Incorporated (OTCBB: ONCS) develops novel OMS ElectroOncology therapies that combine its proprietary electroporation delivery technology with a chemotherapeutic or novel DNA-based immunotherapeutics. Targeted local delivery of these agents is designed to achieve selective destruction of cancerous tumors while sparing healthy normal tissue, resulting in improved functional, cosmetic and quality of life outcomes. These therapieshave achieved validating safety and efficacy data in early and late stage clinical studies of over 400 cancer patients. OncoSec’s clinical programs include three Phase II clinical trials for OMS ElectroImmunotherapy. More information is available at www.oncosec.com. Additional information may also be found at OncoSec’s Facebook , Twitter, and LinkedIn sites.

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This press release contains forward looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Any statements in this release that are not historical facts may be considered such “forward looking statements.” Forward looking statements are based on management’s current preliminary expectations and are subject to risks and uncertainties which may cause ourresults to differ materially and adversely from the statements contained herein. Some of the potential risks and uncertainties that could cause actual results to differ from those predicted include our ability to raise additional funding, our ability to acquire, develop or commercialize new products, uncertainties inherent in pre-clinical studies and clinical trials, unexpected new data, safety and technical issues, competition and market conditions. These and additional risks and uncertainties are more fully described in OncoSec’s filings with the Securities and Exchange Commission. Undue reliance should not be placed on forward looking statements which speak only as of the date they are made. OncoSec disclaims any obligation to update any forward looking statements to reflect new information, events or circumstances after the date they are made, or to reflect the occurrence of unanticipated events.

Preliminary Results of Phase IV Head & Neck Cancer Trial Demonstrate Primary Endpoint Was Achieved; Final Results of Phase I Breast Cancer Trial Show 77% Response Rate

SAN DIEGO, CA, September 26, 2011 — OncoSec Medical Incorporated (OTCBB: ONCS), which is developing its advanced-stage OMS ElectroOncology™ therapies to treat solid tumor cancers, announced today clinical study results presented at the Fire, Ice and Beyond: The Future of Ablation Therapies conference in Las Vegas, NV, September 23-24. OncoSec’s exhibition highlighted a poster titled, “OMS ElectroChemotherapy: Targeted Ablation of Solid Tumors using Reversible Electroporation in Combination with Bleomycin,” which provided preliminary results from their Phase IV head and neck cancer trial and final clinical data from the Phase I breast cancer trials carried out in Europe using OncoSec’s OMS ElectroChemotherapy™ treatment approach.

Phase I Breast Cancer Study

The FDA-approved Phase I study of 13 patients with recurrent breast cancer treated with OncoSec’s OMS ElectroChemotherapy™ demonstrated that the therapy was safe, well-tolerated, and achieved a complete response rate of 77% (10/13) for all patients treated in this study.

The open-label, single-treatment trial in patients with recurrent breast cancer following partial or complete mastectomy used intratumoral administration of bleomycin followed by electroporation to significantly enhance uptake of the drug using OMS ElectroChemotherapy™. No treatment-related serious adverse events were observed. Non-serious adverse events were “unremarkable” during a 30-day follow-up period. Thirteen patients (15 tumors) were enrolled in this study. Excluding one patient lost to follow-up, 10 of the 12 evaluable patients (83%) met the criteria for Complete Response (CR) at 24 weeks.

“The result of this Phase I trial indicates the potential for this local treatment of recurrent breast cancer following partial or complete mastectomy and merits further evaluation,” stated Dr. Paul Goldfarb, OncoSec’s Medical Director.

Preliminary: Phase IV Head & Neck Cancer

This Phase IV registration trial carried out in Europe enrolled 92 patients (53 males and 39 females) with 66 patients followed for up to two years. Mean age at enrollment was 61.0 years (range 20 – 86 years). Seventy-six percent of tumors treated were primary cancers, and 23% were recurrent cancers, with a mean tumor volume for all cancers of 19 cm3. Treatment was found to be safe and well-tolerated with majority of adverse events being pain (77%), infection (50%), edema (48%), and dysphagia (30%). Patient survival following treatment at 8 months was 95% (87/92) and 86% (79/92) at 24 months. In addition, 83% (19/23) of patients with primary tumors treated with bleomycin and electroporation alone at 8 months were disease free. The mean time to onset of recurrence was 379 and 276 days for primary and recurrent disease, respectively. Preliminary analysis of this data demonstrates that the primary endpoint, local control of the tumor at 8 months, was achieved.

A subset of the study results from this Phase IV Recurrent and Primary Cutaneous Head & Neck Cancer Study was published by investigators from Orebro University Hospital in Orebro, Sweden in the medical journal Dermatological Surgery, August 2010, in a paper entitled, “Electroporation Therapy of Skin Cancer in the Head and Neck Area.” A second subset of results from this study was more recently published by the same group of investigators in the journal Acta Oto-Laryngologica, June 2011, in a paper entitled, “Electroporation therapy for T1 and T2 oral tongue cancer.”

Dr. Lennart Lofgren, principal investigator at Obrebro University Hospital and author of the above mentioned articles, said, “OMS ElectroChemotherapy™ has demonstrated promising safety and efficacy results in this patient population, in addition to providing superior functional and cosmetic outcomes for those patients with recurrent or otherwise complicated and difficult to treat skin cancers. This simple and novel delivery of bleomycin, an approved chemotherapeutic agent, through reversible electroporation has shown a marked improvement in potency, while delivering a much lower and safer concentration of the drug.”

“With positive results from these multiple clinical studies, OMS ElectroChemotherapy™ demonstrates clinical benefit for patients with manageable side effects,” said, Punit Dhillon, president and CEO. “We strongly believe in the clinical relevance of our therapeutic approach and believe these results demonstrate tolerability, efficacy and point to the combinability of this novel treatment approach with current available therapies for the management of local tumors. Clinical experience from these programs supports the uniqueness of OMS ElectroChemotherapy™ in its ability to achieve selective destruction of cancerous tumors while sparing healthy normal tissue including highly vascularized and innervated surrounding structures, providing physicians with an important flexible treatment alternative.”

About OncoSec Medical Inc.

OncoSec Medical Incorporated (OTCBB: ONCS) develops novel OMS ElectroOncology therapies that combine its proprietary electroporation delivery technology with a chemotherapeutic or novel DNA-based immunotherapeutics. Targeted local delivery of these agents is designed to achieve selective destruction of cancerous tumors while sparing healthy normal tissue, resulting in improved functional, cosmetic and quality of life outcomes. These therapies have achieved validating safety and efficacy data in early and late stage clinical studies of over 400 cancer patients. OncoSec’s clinical programs include three Phase II clinical trials. More information is available at www.oncosec.com.

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This press release contains forward looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Any statements in this release that are not historical facts may be considered such “forward looking statements.” Forward looking statements are based on management’s current preliminary expectations and are subject to risks and uncertainties which may cause our results to differ materially and adversely from the statements contained herein. Some of the potential risks and uncertainties that could cause actual results to differ from those predicted include our ability to raise additional funding, our ability to acquire, develop or commercialize new products, uncertainties inherent in pre-clinical studies and clinical trials, unexpected new data, safety and technical issues, competition and market conditions. These and additional risks and uncertainties are more fully described in OncoSec’s filings with the Securities and Exchange Commission. Undue reliance should not be placed on forward looking statements which speak only as of the date they are made. OncoSec disclaims any obligation to update any forward looking statements to reflect new information, events or circumstances after the date they are made, or to reflect the occurrence of unanticipated events.


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