Clinical Trials, Data, and Staging

Clinical Trials, Data, and Staging

The biotech and medical industries have come a long way. While many marvels have been created – such as vaccines, treatments and prosthetics – some of the research could pose dangers to the public, if it is not used correctly or if the initial findings from early experimentation are wrong. It is for these reasons that the FDA requires proper clinical testing (or clinical trials) to be performed, before they are eligible for public use. We would like to explore what exactly a clinical trial is, the data they collect and how a clinical trial moves on to the next phase:

Blossom Ball 2013 and OncoSec Medical

As a CEO, there are many different ways to cause or affect change. Being a corporate influencer puts you not only at the forefront of your company’s decision-making process but also in talks with many other CEOs and industry professionals. With this power also comes the chance for positive social partnerships that can benefit individuals, communities, societies and even the world. CEOs Against Cancer aims to do just that; bringing together CEOs from across the world, in order to help save lives, through cancer prevention and research. This Saturday, May 11th, members of CEO’s Against Cancer will be attending the annual Blossom Ball, to raise funds for the American Cancer Society.

cutaneous t-cell lymphoma, cancer, oncosec, medical, research, microscope, treatment

 

Skin cancer has long been something closely associated with sun exposure. Despite how often some cancers are caused by a history of extended periods of contact with sunlight, there are some skin cancers that have not been related to this at all. Some of these may be fatal while others are thought of as completely non-fatal conditions. One such cancer is cutaneous T-cell lymphoma. While treatable, there is no cure for this condition and many patients will live with this cancer for the rest of their lives.

SAN DIEGO, CA — July 30, 2012 OncoSec Medical Inc. (OTCBB:ONCS), which is developing its advanced-stage OMS ElectroOncology therapies to treat solid tumor cancers, announced it has received notified body certification to the International Organization for Standardization’s (ISO) 13485 standard for the “design, development, manufacture, and distribution of electroporation devices”. The certification confirms the company’s Quality Management System (QMS) and that the company’s manufacturing processes are controlled, documented and compliant with the stringent requirements set by the European Union.

“The ISO certification is a significant accomplishment and an important milestone for OncoSec. Certification affirms that our QMS meets the highest standards and strengthens OncoSec’s commitment to product quality and development,” said Punit Dhillon, President and CEO. “With this certification in place, OncoSec is now one major step closer to obtaining the CE Marking necessary for commercialization in Europe.”

Companies receiving the ISO 13485 certification must demonstrate an ability to provide medical devices and related services that consistently meet customer and regulatory requirements. Achievement of ISO certification offers customers and suppliers an additional level of confidence in the quality and reliability of OncoSec devices, as well as, the company’s commitment to continuous improvement. OncoSec’s review was performed by SGS, a world leader among notified bodies in inspection, verification, testing, and certification.

OncoSec’s electroporation device, the OncoSec Medical System (OMS), is currently being used in three on-going clinical trials for the treatment of metastatic melanoma, Merkel cell carcinoma and cutaneous T-cell lymphoma. In addition, the OMS has been used in Europe in Phase IV clinical trials for the treatment of head and neck cancer and cutaneous and subcutaneous skin cancers.

SAN DIEGO, CA, May 29, 2012 — OncoSec Medical Inc. (OTCBB:ONCS), which is developing its advanced-stage OncoSec Medical System(OMS) ElectroOncology therapies to treat solid tumor cancers, issued the following letter to Shareholders today:

Dear Shareholder:
As we near the mid-point of 2012, OncoSec is successfully executing on its objectives for the year. I want to review the key developments so you can see why all of us at OncoSec are so excited.

Financial Update

  • Strengthened balance sheet: OncoSec recently raised $7.75 million through a public offering underwritten by Rodman & Renshaw, with Roth Capital Partners acting as an advisor. We are now well financed to continue our promising clinical development programs. We currently have over $6.5 million in cash reserves to fund operations, which should be sufficient to complete our current studies.

Clinical Update
We are executing our clinical development plan based on our novel, first-in-class OMS ElectroImmunotherapy platform for the treatment of rare and deadly skin cancers including metastatic melanoma, Merkel cell carcinoma and cutaneous T-cell lymphoma.

  • OMS-I100: We initiated and enrolled several patients in OMS-I100, a Phase II study for the treatment of metastatic melanoma led by the University of California at San Francisco, with additional sites at the John Wayne Cancer Institute in Santa Monica and Lakeland Comprehensive Cancer Center in Lakeland, Florida. We expect to report interim clinical data before year end.
  • OMS-I110: We initiated and enrolled several patients in OMS-I110, a Phase II study for the treatment of Merkel cell carcinoma led by the University of Washington and the Fred Hutchinson Cancer Center in Seattle, Washington. We expect to report interim clinical data before year end.
  • OMS-I120: We aim to initiate and begin enrolling patients in OMS-I120, a Phase II study for the treatment of cutaneous T-cell lymphoma (CTCL) by year-end. This study will be led by the University of California at San Francisco and include multiple centers across the US.
  • Expansion of technology platform: We are pursuing clinical and regulatory development of our OMS ElectroChemotherapy in the U.S., Europe and Asia, including the development of new indications for ElectroChemotherapy. The last several months have demonstrated our ability to create incremental value from our advanced-stage OMS ElectroChemotherapy program for the treatment of primary and recurrent localized solid tumors. Since the acquisition of a clinical data set of over 400 patients, we have compiled, reviewed, and analyzed the data and presented preliminary results from a Phase IV European head & neck cancer trial and Phase I/II breast cancer trial. The preliminary data sets from the completed Phase III recurrent head and neck cancer studies carried out in the U.S. are now being analyzed, and we intend to present this data at the 5th International Head and Neck Cancer Conference taking place July 21-25. We are defining a regulatory path with the FDA forclinical development of advanced stage skin cancer and other solid tumor indications. In addition, we are advancing a commercialization strategy focused on creating regional partnerships or establishing a global partner to develop the market potential for OMS ElectroChemotherapy in Europe, Asia and other emerging markets.

Corporate Update

  • Patent portfolio expansion. We are developing new applications of our OMS ElectroOncology for treating solid tumors and metastatic disease, with the goal of expanding our market opportunities and establishing additional patents to maintain our dominance in these areas.
  • Gaining leadership position and creating awareness: We have been able to build physician, partner, and patient awareness of the clinical development of OMS ElectroImmunotherapy for the treatment of metastatic melanoma and Merkel cell carcinoma through the media. These publications include: Xconomy, Medical Device & Diagnostic Industry, Manufacturing Chemist, and the San Diego Business Journal. OMS ElectroImmunotherapy was also featured as a “revolutionary cancer treatment” for Merkel cell carcinoma by a local NBC News affiliate in Seattle, Washington. We continue our proactive outreach to inform relevant audiences of technology and business opportunities.

OncoSec sees the initial market for its OMS ElectroImmunotherapy exceeding $500 million in the U.S. alone. Melanoma andother skin cancers are deadly diseases with very limited treatment options (i.e. limited competition). We have a highly focused effort to develop a new generation of immunotherapy products to provide better care to these patients and we are passionate about the progress of our programs.

I thank you for your ongoing support as we work toward our goal of becoming the preeminent developer of targeted oncology therapies. Ilook forward to updating you on our continued progress in the year ahead.

Best regards,
Punit Dhillon
President and CEO

About OncoSec Medical Inc.

OncoSec Medical Incorporated (OTCBB: ONCS) develops novel OMS ElectroOncology therapies that combine its proprietary electroporation delivery technology with a chemotherapeutic or novel DNA-based immunotherapeutics. Targeted local delivery of these agents is designed to achieve selective destruction of cancerous tumors while sparing healthy normal tissue, resulting in improved functional, cosmetic and quality of life outcomes. These therapieshave achieved validating safety and efficacy data in early and late stage clinical studies of over 400 cancer patients. OncoSec’s clinical programs include three Phase II clinical trials for OMS ElectroImmunotherapy. More information is available at www.oncosec.com. Additional information may also be found at OncoSec’s Facebook , Twitter, and LinkedIn sites.

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This press release contains forward looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Any statements in this release that are not historical facts may be considered such “forward looking statements.” Forward looking statements are based on management’s current preliminary expectations and are subject to risks and uncertainties which may cause ourresults to differ materially and adversely from the statements contained herein. Some of the potential risks and uncertainties that could cause actual results to differ from those predicted include our ability to raise additional funding, our ability to acquire, develop or commercialize new products, uncertainties inherent in pre-clinical studies and clinical trials, unexpected new data, safety and technical issues, competition and market conditions. These and additional risks and uncertainties are more fully described in OncoSec’s filings with the Securities and Exchange Commission. Undue reliance should not be placed on forward looking statements which speak only as of the date they are made. OncoSec disclaims any obligation to update any forward looking statements to reflect new information, events or circumstances after the date they are made, or to reflect the occurrence of unanticipated events.

SAN DIEGO, CA, April 10, 2012 — OncoSec Medical Inc. (OTCBB:ONCS), which is developing its advanced-stage OncoSec Medical System(OMS) ElectroOncology therapies to treat solid tumor cancers, today announced that Punit Dhillon, President and CEO, and Michael Cross, Ph.D., MBA have contributed an article for the April 2012 issue of Manufacturing Chemist reviewing current strategies for the treatment of solid tumors. In addition, a feature was written in the April 9, 2012 edition of the San Diego Business Journal, which profiles OncoSec’s technology and development plan.

The article featured in Manufacturing Chemist, titled “Novel approaches to tumor treatment” outlines therapeutic treatments currently available to cancer patients such as electroporation, which is able to specifically target the solid cancer tumor itself without affecting any of the surrounding healthy tissue.

To read an excerpt of the article, please visit the following link:
http://www.manufacturingchemist.com/technical/article_page/Novel_approaches_to_tumour_treatment/77234

The company profile featured in San Diego Business Journal, titled “OncoSec Inches Ahead on Skin Cancer Zapping Technology” discusses OncoSec’s development plan, highlighting the company’s OMS ElectroImmunotherapy program for the treatment of Merkel cell carcinoma, metastatic melanoma andcutaneous T-cell lymphoma. This article is only available online to subscribers of the San Diego Business Journal

To read the article in its entirety, please visit the following link and subscribe:
http://sdbj.com/accounts/login/?next=/news/2012/apr/09/oncosec-inches-ahead-skin-cancer-zapping-technolog/

About OncoSec Medical Inc.

OncoSec Medical Incorporated (OTCBB: ONCS) develops novel OMS ElectroOncology therapies that combine its proprietary electroporation delivery technology with a chemotherapeutic or novel DNA-based immunotherapeutics. Targeted local delivery of these agents is designed to achieve selective destruction of cancerous tumors while sparing healthy normal tissue, resulting in improved functional, cosmetic and quality of life outcomes. These therapieshave achieved validating safety and efficacy data in early and late stage clinical studies of over 400 cancer patients. OncoSec’s clinical programs include three Phase II clinical trials for OMS ElectroImmunotherapy. More information is available at www.oncosec.com. Additional information may also be found at OncoSec’s Facebook , Twitter, and LinkedIn sites.

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This press release contains forward looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Any statements in this release that are not historical facts may be considered such “forward looking statements.” Forward looking statements are based on management’s current preliminary expectations and are subject to risks and uncertainties which may cause ourresults to differ materially and adversely from the statements contained herein. Some of the potential risks and uncertainties that could cause actual results to differ from those predicted include our ability to raise additional funding, our ability to acquire, develop or commercialize new products, uncertainties inherent in pre-clinical studies and clinical trials, unexpected new data, safety and technical issues, competition and market conditions. These and additional risks and uncertainties are more fully described in OncoSec’s filings with the Securities and Exchange Commission. Undue reliance should not be placed on forward looking statements which speak only as of the date they are made. OncoSec disclaims any obligation to update any forward looking statements to reflect new information, events or circumstances after the date they are made, or to reflect the occurrence of unanticipated events.

Active Investor and Media Outreach to Build Company Awareness

SAN DIEGO, CA, December 14, 2011 — OncoSec Medical Inc.(OTCBB:ONCS), a biotechnology company developing its advanced-stage Oncology Medical System (OMS) ElectroOncology therapies to treat skin cancer and other solid tumor cancers, has hired The Investor Relations Group (“IRG”), a fifteen-year-old, award-winning, corporate communications firm based in NewYork City, to serve as its investor relations and public relations agency.

IRG’s investor relations team will target specific portfolio managers and equity analysts in the global investment community to increasea wareness of OncoSec Medical’s therapies, which combine the Company’s proprietary electroporation delivery technology with a chemotherapeutic or novel DNA-based immunotherapeutic. Concurrent with that effort, the public relations team will initiate an outreach campaign targeting editors, writers, and segment producers of local and national trade and consumer online, print, radio, and broadcast media outlets worldwide.

“OncoSec Medical has outlined a bold set of initiatives for 2012 and beyond, and we are confident that IRG will serve as an excellent liaison to the investment community and the media at large,” commented Punit Dhillon, President and Chief Executive Officer. “We are especially looking forward to initiating and obtaining results from our three Phase II safety and efficacy trials, which will use our OMS ElectroImmunotherapy technology to deliver DNA IL-12 to patients with metastatic melanoma, Merkel cell carcinoma, and cutaneous t-cell lymphoma. With our extensive clinical experience, and positive results from the Phase I malignant melanoma study which demonstrated best-in-class local and systemic responses, we strongly believe that our electroporation delivery technology offers a uniquely powerful and compelling new approach to treating solid tumor cancers. We look forward to working with IRG as we achieve our objectives andwill update the investment community as we move ahead.”

IRG’s corporate communications program includes new media and multimedia initiatives that involve the creation of broadcast-ready corporate videos, podcasts, and the creation of social networking, video service, and micro-blogging accounts. The Investor Relations Group was recently honored with a “Stevie Award” for Investor Relations Program of the Year and named a finalist in the BestMedia Website category from the 2009 American Business Awards.

About OncoSec Medical Inc.

OncoSec Medical Incorporated (OTCBB: ONCS) develops novel OMS ElectroOncology therapies that combine its proprietary electroporation delivery technology with a chemotherapeutic or novel DNA-based immunotherapeutics. Targeted local delivery of these agents is designed to achieve selective destruction of cancerous tumors while sparing healthy normal tissue, resulting in improved functional, cosmetic and quality of life outcomes. These therapieshave achieved validating safety and efficacy data in early and late stage clinical studies of over 400 cancer patients. OncoSec’s clinical programs include three Phase II clinical trials for OMS ElectroImmunotherapy. More information is available at www.oncosec.com. Additional information may also be found at OncoSec’s Facebook , Twitter, and LinkedIn sites.

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This press release contains forward looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Any statements in this release that are not historical facts may be considered such “forward looking statements.” Forward looking statements are based on management’s current preliminary expectations and are subject to risks and uncertainties which may cause ourresults to differ materially and adversely from the statements contained herein. Some of the potential risks and uncertainties that could cause actual results to differ from those predicted include our ability to raise additional funding, our ability to acquire, develop or commercialize new products, uncertainties inherent in pre-clinical studies and clinical trials, unexpected new data, safety and technical issues, competition and market conditions. These and additional risks and uncertainties are more fully described in OncoSec’s filings with the Securities and Exchange Commission. Undue reliance should not be placed on forward looking statements which speak only as of the date they are made. OncoSec disclaims any obligation to update any forward looking statements to reflect new information, events or circumstances after the date they are made, or to reflect the occurrence of unanticipated events.

SAN DIEGO, Ca., November 21, 2011 — OncoSec Medical Inc. (OTCBB: ONCS), which is developing its advanced stage ElectroOncology therapies to treat solid tumor cancers, announced today the appointment of three respected medical innovators to its newly created Scientific Advisory Board (SAB). This advisory board will provide input to the company’s R&D and clinical strategies, including OncoSec’s multiple planned Phase II clinical trials for the treatment of melanoma, Merkel cell carcinoma and cutaneous T-cell lymphoma.

The internationally recognized leaders in medical research joining OncoSec’s Scientific Advisory Board are:

  • Richard Heller, Ph.D. – Director, Frank Reidy Research Center for Bioelectrics, Old Dominion University
  • Iacob Mathiesen, Ph.D. – CEO, Otivio AS
  • Christian H. Ottensmeier, MD, Ph.D. – Professor of Experimental Cancer Research at the University of Southampton

The SAB will meet bi-annually to review the company’s progress in research and clinical development as well as to evaluate new scientific perspectives alongside the company’s management. In addition, OncoSec and the Scientific Advisory Board will rely on input and expertise from the Company’s clinical and scientific advisory panel, which notably includes:

  • Adil Daud, M.D. – Clinical Professor and Director Melanoma Program, University of California, San Francisco
  • Paul Nghiem, M.D., Ph.D. – Associate Professor, Dermatology, University of Washington
  • Shailender Bhatia, M.D. – Assistant Professor, Medical Oncology, University of Washington
  • Wei Ai, M.D. – Clinical Assistant Professor, Hematology and Oncology, University of California, San Francisco
  • Siegrid Yu, M.D. – Assistant Clinical Professor, Dermatology, University of California, San Francisco
  • Alain Rook, M.D. – Professor of Dermatology, University of Pennsylvania

Punit Dhillon, OncoSec’s president and CEO, said, “We are very pleased to welcome such respected research and clinical leaders to OncoSec’s Scientific Advisory Board. They are all recognized as innovators in their scientific and medical fields. In combination with members of our clinical and scientific advisory panel we feel that OncoSec has brought together an incredibly strong group of scientific minds who will help to guide the development and commercialization strategies for our OMS ElectroOncology therapies.”

Below is more information on OncoSec’s new Scientific Advisory Board members:

RICHARD HELLER, PH.D.
Dr. Heller has over 25 years experience in evaluating effects of electric pulses on biological systems. He is recognized as a pioneer on the use of electroporation for drug and gene delivery and holds multiple patents related to the use of electric fields for molecule delivery. A major focus of his research is to develop in vivo delivery procedures for non-viral gene therapy. The approach utilizes pulsed electric fields to facilitate targeting and uptake of the molecules to be delivered. His laboratory has multiple publications reporting on new protocols or devices that are being tested for potential therapies for cancer, wound healing and vascular diseases (peripheral or coronary ischemia) as well as vaccine and immunotherapy protocols including one of the first publications demonstrating the use of in vivo electroporation to deliver plasmid DNA. The immune-gene therapy approach developed in his laboratory was translated into the clinic and represents the first-in-human study utilizing in vivo electro-gene delivery of a plasmid for the treatment of melanoma. Dr. Heller received his B.S. degree in Microbiology from Oregon State University, a M.S. from Long Island University, C. W. Post campus in Health Sciences and a Ph.D. in Medical Sciences from the University of South Florida, College of Medicine. He was a Professor in the Departments of Molecular Medicine and Surgery at USF College of Medicine prior to joining Old Dominion University in 2008.

IACOB MATHIESEN, PH.D.
Iacob Mathiesen has been a pioneer in the advancement of novel electroporation methods and devices for DNA delivery. He co-founded Inovio AS in 1999, a research and development company which pursued advancements in the field of electroporation-based DNA delivery and was successful in securing pivotal patents, developing leading edge devices, and securing strategic partnerships. As the CEO of the company he was instrumental in raising capital, negotiating license agreements and research collaborations as well as developing clinically approved medical devices for gene delivery to humans. Inovio & University of Southampton initiated the first clinical trial in the world using electroporation to deliver DNA vaccines. He led the company until Inovio in 2005 was acquired by Genetronics Biomedical Corporation, a US listed company which subsequently changed name to Inovio Pharmaceuticals (www.inovio.com, NYSE Amex: INO). He has been named as inventor or co-inventor on multiple patents and co-authored numerous scientific papers relating to the use of electroporation for DNA delivery. Iacob led the merged company’s R&D efforts related to gene delivery (DNA vaccines and gene therapy). He is currently a member of Inovio’s scientific advisory board. Iacob received a B.Sc. in Mathematics and Natural Sciences in 1991, an M.Sc. in Mathematics and Natural Sciences in 1993, and a Ph.D. in Neurobiology in 1999, all from the University of Oslo, Norway. He was a co-founder of Otivio AS in 2010 and is a board member of Connect in Norway, an international organization for helping entrepreneurs.

CHRISTIAN OTTENSMEIER, M.D., PH.D.
Christian Ottensmeier is Professor in Experimental Cancer Medicine. Following a 3 year training fellowship at the Dana Farber Cancer Institute in Boston, Massachusetts, he moved to Southampton. Professor Ottensmeier has been a consultant in medical oncology since 2000. Clinically his interests are thoracic malignancies and melanoma, and he has helped to develop several of national NCRI studies in lung cancer. He manages a broad and active clinical trials portfolio in both lung cancer and melanoma. The overarching aim of his laboratory group is the preclinical development and early phase clinical testing of strategies to induce anti-tumour immune responses in patients. After an initial focus on B cell malignancies the majority of the work is now in solid tumours. This has led to three linked but distinct areas of investigation: Detailed immunological evaluation of the effect of immunological intervention in patients, assay development and validation, and finally mechanistic studies in murine models as well as human modeling of immune responses to vaccination for further preclinical cancer vaccine development.

About OncoSec Medical Inc.

OncoSec Medical Incorporated (OTCBB: ONCS) develops novel OMS ElectroOncology therapies that combine its proprietary electroporation delivery technology with a chemotherapeutic or novel DNA-based immunotherapeutics. Targeted local delivery of these agents is designed to achieve selective destruction of cancerous tumors while sparing healthy normal tissue, resulting in improved functional, cosmetic and quality of life outcomes. These therapies have achieved validating safety and efficacy data in early and late stage clinical studies of over 400 cancer patients. OncoSec’s clinical programs include three Phase II clinical trials for OMS ElectroImmunotherapy. More information is available at www.oncosec.com. Additional information may also be found at OncoSec’s Facebook , Twitter, and LinkedIn sites.

* * *

This press release contains forward looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Any statements in this release that are not historical facts may be considered such “forward looking statements.” Forward looking statements are based on management’s current preliminary expectations and are subject to risks and uncertainties which may cause our results to differ materially and adversely from the statements contained herein. Some of the potential risks and uncertainties that could cause actual results to differ from those predicted include our ability to raise additional funding, our ability to acquire, develop or commercialize new products, uncertainties inherent in pre-clinical studies and clinical trials, unexpected new data, safety and technical issues, competition and market conditions. These and additional risks and uncertainties are more fully described in OncoSec’s filings with the Securities and Exchange Commission. Undue reliance should not be placed on forward looking statements which speak only as of the date they are made. OncoSec disclaims any obligation to update any forward looking statements to reflect new information, events or circumstances after the date they are made, or to reflect the occurrence of unanticipated events.

SAN DIEGO, CA, October 20, 2011 — OncoSec Medical Incorporated (OTCBB: ONCS), which is developing its advanced-stage OMS ElectroOncology therapies for the treatment of solid tumor cancers, announced today the submission of its Device Master File (DMF) to the U.S. Food and Drug Administration (FDA) for its patented OncoSec Medical System (OMS) which consists of a generator and hand-held applicator. The Company has been developing the OncoSec Medical System as its lead medical device for delivering DNA based cytokines and chemotherapeutic agents for the treatment of solid tumor cancers. In numerous Phase I through Phase IV clinical trials, the OncoSec Medical System has been shown to be both safe and effective for optimizing the cellular uptake of DNA based cytokines or chemotherapeutic agents resulting in improved therapeutic benefits for the patient.

The DMF, which includes technical, manufacturing, clinical and non-clinical information about the OncoSec Medical System, marks an important milestone for the Company. This regulatory filing facilitates FDA review of the complete system when any investigational clinical study application references its use.

“This DMF submission brings the OncoSec Medical System another step closer to becoming the treatment of choice for different types of solid tumor cancers,” stated Punit Dhillon, President and Chief Executive Officer of OncoSec. “In a very short period of time, OncoSec has moved aggressively with its clinical and regulatory strategy, with the DMF being one important piece of that strategy. Moving forward, we will continue to demonstrate the value of our treatment approaches as our clinical studies begin.”

OncoSec plans to initiate three Phase II clinical trials under physician sponsored INDs using the OncoSec Medical System to deliver DNA IL-12: OMS-I100 for the treatment of melanoma; OMS-I120 for the treatment of Merkel cell carcinoma; and OMS-I130 for the treatment of cutaneous T-cell lymphoma.

About OncoSec Medical Inc.

OncoSec Medical Incorporated (OTCBB: ONCS) develops novel OMS ElectroOncology therapies that combine its proprietary electroporation delivery technology with a chemotherapeutic or novel DNA-based immunotherapeutics. Targeted local delivery of these agents is designed to achieve selective destruction of cancerous tumors while sparing healthy normal tissue, resulting in improved functional, cosmetic and quality of life outcomes. These therapies have achieved validating safety and efficacy data in early and late stage clinical studies of over 400 cancer patients. OncoSec’s clinical programs include three Phase II clinical trials. More information is available at www.oncosec.com.

* * *
This press release contains forward looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Any statements in this release that are not historical facts may be considered such “forward looking statements.” Forward looking statements are based on management’s current preliminary expectations and are subject to risks and uncertainties which may cause our results to differ materially and adversely from the statements contained herein. Some of the potential risks and uncertainties that could cause actual results to differ from those predicted include our ability to raise additional funding, our ability to acquire, develop or commercialize new products, uncertainties inherent in pre-clinical studies and clinical trials, unexpected new data, safety and technical issues, competition and market conditions. These and additional risks and uncertainties are more fully described in OncoSec’s filings with the Securities and Exchange Commission. Undue reliance should not be placed on forward looking statements which speak only as of the date they are made. OncoSec disclaims any obligation to update any forward looking statements to reflect new information, events or circumstances after the date they are made, or to reflect the occurrence of unanticipated events.

SAN DIEGO, CA, October 4, 2011 — OncoSec Medical Incorporated (OTCBB: ONCS), which is developing its advanced-stage OMS ElectroOncology™ therapies to treat solid tumor cancers, announced today that the OncoSec Medical System (OMS) devices have been qualified and released and are now ready for shipment to clinical sites in time for the upcoming OMS ElectroImmunotherapy™ clinical trials.

In March 2011 OncoSec acquired the rights to an electroporation delivery technology platform that can be used to efficiently deliver a chemotherapeutic or DNA-based cytokine agent for the treatment of solid tumors, which OncoSec has branded as the OncoSec Medical System (OMS). Since then, projects were initiated to establish engineering and manufacturing capabilities, as well as, transfer and update regulatory, design and manufacturing documentation, including implementing a new quality assurance system. Over the course of five months a manufacturing plan was executed to ensure that the devices acquired by OncoSec were safe and ready for use in clinical trials. The company now has inventory of OMS investigational devices adequate to support known and anticipated clinical study requirements well into 2013. OncoSec’s current infrastructure and facility is designed to support manufacturing, assembly, testing, technical and regulatory support for multiple clinical trials in compliance with FDA and quality systems regulations. The extent of OncoSec manufacturing operations allow the company to build and maintain the current device supply to support on-going and future clinical trials, scale up production as needed as well as design and develop a next generation OMS electroporation system. The company utilizes contract manufacturers for key operations, such as clean room assembly and sterilization, which are not presently economically conducted in-house.

“Since acquiring the technology our team has worked diligently to test, and re-test, the OMS device to ensure that it is safe and ready for in-human use, as well as, manufacture new applicators and applicator handles for the OMS ElectroImmunotherapy™ clinical trials. I am delighted to report that they are now ready for shipment to the clinical sites,” said, Dr. Michael Cross, OncoSec’s Chief Business Officer, “This milestone also highlights the fact that OncoSec now has the in-house capabilities to build, maintain and develop our own devices, while still having the flexibility to outsource specific manufacturing activities, where required, thereby allowing OncoSec to hold strict control over manufacturing costs.”

OncoSec intends to initiate three Phase II clinical trials using the OMS ElectroImmunotherapy™ treatment approach for melanoma, Merkel cell carcinoma and cutaneous T-cell lymphoma by the end of October 2011. “The release of these devices is an integral step in our development plan. With the achievement of this milestone, we continue to meet the goals set out by our corporate strategy, and expect to move toward validating the data seen in the Phase I study in our upcoming clinical trials.,” said Punit Dhillon, President and CEO.

About OncoSec Medical Inc.

OncoSec Medical Incorporated (OTCBB: ONCS) develops novel OMS ElectroOncology therapies that combine its proprietary electroporation delivery technology with a chemotherapeutic or novel DNA-based immunotherapeutics. Targeted local delivery of these agents is designed to achieve selective destruction of cancerous tumors while sparing healthy normal tissue, resulting in improved functional, cosmetic and quality of life outcomes. These therapies have achieved validating safety and efficacy data in early and late stage clinical studies of over 400 cancer patients. OncoSec’s clinical programs include three Phase II clinical trials. More information is available at www.oncosec.com.

* * *
This press release contains forward looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Any statements in this release that are not historical facts may be considered such “forward looking statements.” Forward looking statements are based on management’s current preliminary expectations and are subject to risks and uncertainties which may cause our results to differ materially and adversely from the statements contained herein. Some of the potential risks and uncertainties that could cause actual results to differ from those predicted include our ability to raise additional funding, our ability to acquire, develop or commercialize new products, uncertainties inherent in pre-clinical studies and clinical trials, unexpected new data, safety and technical issues, competition and market conditions. These and additional risks and uncertainties are more fully described in OncoSec’s filings with the Securities and Exchange Commission. Undue reliance should not be placed on forward looking statements which speak only as of the date they are made. OncoSec disclaims any obligation to update any forward looking statements to reflect new information, events or circumstances after the date they are made, or to reflect the occurrence of unanticipated events.


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