Paging Dr. Pierce: OncoSec CMO Discusses the Need for Combination Therapies

Paging Dr. Pierce: OncoSec CMO Discusses the Need for Combination Therapies
“Let’s talk about the need for combinatorial approaches in oncology therapy – in particular, for immunotherapies.”

On Tumor Immune Evasion

Tumors deploy multiple parallel mechanisms that synergize – meaning that they work together to get more bang for their buck. In this way, tumors are able to subvert the immune response and protect themselves from being eradicated by the immune system. Thus, we need to similarly deploy multiple parallel synergistic mechanisms to re-program the immune response – to re-hijack it from tumors.

It is very rare that you find a patient with a tumor that has a dominant immune checkpoint – where you can simply reverse that one mechanism and see an effect. To put it frankly, we need to move towards combination approaches in immunotherapy.

What is Combination Therapy?

More and more, a one-size-fits-all approach to medicine has been shown to simply be ineffective. With resistant strains of disease, genetic differences in patients and the requirement for more effective (yet less damaging) treatment options, modern medicine is beginning to change its approach. With more attention paid towards personalized medicine, attempts at fewer side effects and ongoing research into gene therapy and immunotherapy, we are now seeing a pronounced shift. One method gaining a lot of attention is combination therapy.


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