Melanoma Re-cap

Melanoma Re-cap

As one of the cancer types that we at OncoSec concentrate on, we are constantly involved in not only developing an alternative treatment for melanoma but also evaluating the public and professional knowledge base surrounding the development, prevention and awareness of the disease. As a company directly involved in the research side, we are constantly inundated with statistics and methods. However, much of the general public is still unaware of the potentially deadly consequences of melanoma. Perhaps it is due to the relatively small size of moles, an increase in survival rates or the predominance of tanning but something in our culture needs a serious shift, if we are going to collectively work towards better preventative measures.

Exams, Screenings and Early Detection

There are many factors that can influence the risk of cancer in an individual. Whether it is sunburns and melanoma, smoking and the lungs, or nitrates and the kidneys/pancreas, there are many human activities that are known to increase the risk of cancer. Cancer symptoms and warning signs may not always be apparent: it’s one of the reasons many cancers are often not caught at an early stage. Without exams and screenings, cancer can often develop into a late stage, before signs become apparent. It is because of this that awareness around exams and screenings is so important.

OncoSec's ImmunoPulse Immunotherapy Treatment for Melanoma

 

While easily the most prominent and well-known skin cancer, melanoma can either be quite slow moving (remaining in the skin) or aggressive (moving to remote areas of the body). Thankfully, many cases are caught in their early cases and surgeons are able to remove malignant areas. However, for more aggressive instances of melanoma, treatment has shown to have debilitating side effects for patients, and, the later the stage of the cancer, the more challenging it is to treat with traditional methods. Be that as it may, recent evidence has suggested that the immune system may be the key to a higher-rate of successful later-stage treatment, as well as being less harmful and intrusive for cancer patients.

California Sun

 

When researching and actively working towards the treatment of an emerging condition, it is important to pay close attention to the history of the disease and how it might help move forward the field of study and public awareness. Being a lesser-known form of cancer, Merkel cell carcinoma (MCC) has not been paid as close attention as its mortality rate should merit. At OncoSec, we believe that it is of high importance to advance the field of study surrounding MCC and to create a more effective treatment regimen.

metastatic, melanoma, oncosec, medical, gene therapy, clouds, sun, medical trials

 

As the largest organ of the body, the skin protects us from a myriad of conditions, parasites, and other foreign agents. Be that as it may, it is also highly susceptible to different diseases, viruses, and cancers. Different skin types can be more resistant or more susceptible to different conditions. One type of cancer that aggressively attacks the skin is melanoma: the later stage of which is known as metastatic melanoma.

cutaneous t-cell lymphoma, cancer, oncosec, medical, research, microscope, treatment

 

Skin cancer has long been something closely associated with sun exposure. Despite how often some cancers are caused by a history of extended periods of contact with sunlight, there are some skin cancers that have not been related to this at all. Some of these may be fatal while others are thought of as completely non-fatal conditions. One such cancer is cutaneous T-cell lymphoma. While treatable, there is no cure for this condition and many patients will live with this cancer for the rest of their lives.

SAN DIEGO, CA — July 30, 2012 OncoSec Medical Inc. (OTCBB:ONCS), which is developing its advanced-stage OMS ElectroOncology therapies to treat solid tumor cancers, announced it has received notified body certification to the International Organization for Standardization’s (ISO) 13485 standard for the “design, development, manufacture, and distribution of electroporation devices”. The certification confirms the company’s Quality Management System (QMS) and that the company’s manufacturing processes are controlled, documented and compliant with the stringent requirements set by the European Union.

“The ISO certification is a significant accomplishment and an important milestone for OncoSec. Certification affirms that our QMS meets the highest standards and strengthens OncoSec’s commitment to product quality and development,” said Punit Dhillon, President and CEO. “With this certification in place, OncoSec is now one major step closer to obtaining the CE Marking necessary for commercialization in Europe.”

Companies receiving the ISO 13485 certification must demonstrate an ability to provide medical devices and related services that consistently meet customer and regulatory requirements. Achievement of ISO certification offers customers and suppliers an additional level of confidence in the quality and reliability of OncoSec devices, as well as, the company’s commitment to continuous improvement. OncoSec’s review was performed by SGS, a world leader among notified bodies in inspection, verification, testing, and certification.

OncoSec’s electroporation device, the OncoSec Medical System (OMS), is currently being used in three on-going clinical trials for the treatment of metastatic melanoma, Merkel cell carcinoma and cutaneous T-cell lymphoma. In addition, the OMS has been used in Europe in Phase IV clinical trials for the treatment of head and neck cancer and cutaneous and subcutaneous skin cancers.

SAN DIEGO, CA — June 14, 2012 — OncoSec Medical Incorporated (OTCBB: ONCS, a company developing the advanced-stage OncoSec Medical System (OMS) ElectroOncology therapies to treat solid tumors, announced it will be presenting at a series of investor and scientific conferences in upcoming weeks.

Investor Conferences

Punit Dhillon, President and CEO, will be presenting a corporate overview of OncoSec, including its portfolio and investment highlights, at the following conferences:

Bio International Convention, Boston, MA, June18-21, 9:00 am ET

Marcum MicroCap Conference, New York, NY, June 20, 11:30 am ET
A live and archived webcast of Mr. Dhillon’s presentation will be accessible on the OncoSec website, www.OncoSec.com. Please allow 15 minutes prior to the presentation to allow for any softwaredownloads.

OneMedForum NY 2012, New York, NY, July 12, Time to be confirmed

Scientific Conferences

In addition, OncoSec will be providing an update on its cancer immunotherapy program and on-going clinical trials at the following conferences:

2nd European Post-Chicago Melanoma Meeting, Munich, Germany, June 21-22, 9:48 CET
Presented by Dr. Adil Daud MD, Principal Investigator

10th Annual Vaccines Research and Development: All Things ConsideredConference, San Francisco, CA, July 10, 11:05 am PT
Presented by Punit Dhillon, CEO

The Company will also be presenting a poster containing data from a Phase III study of the OMS ElectroChemotherapy therapy at the following conference:

8th International Conference on Head and Neck Cancer, Toronto, Canada, July 22-24

About OncoSec Medical Inc.

OncoSec Medical Incorporated is a biopharmaceuticalcompany developing advanced-stage OMS ElectroOncology therapies to treat solid tumor cancers and metastatic disease. OMS ElectroOncology therapies address an unmet medical need and represent apotential solution for less invasive and less expensive therapies that are able to minimize detrimental effects resulting from traditional cancer treatments. OncoSec’s core technology is based upon its proprietary use of an electroporation platform, to dramatically enhance the delivery and uptake of a locally delivered DNA-based immuno-cytokine or a chemotherapeutic agent. Treatment of various solid cancers using these targeted anti-cancer agents has demonstrated selective destruction of cancerous cells while sparing healthy normal tissues during early and late stage clinical trials. OncoSec’s clinical programs include three Phase II clinical trials for OMS ElectroImmunotherapy targeting lethal skin cancers. More information is available at www.oncosec.com.

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This press release contains forward looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Any statements in this release that are not historical facts may be considered such “forward looking statements.” Forward looking statements are based on management’s current preliminary expectations and are subject to risks and uncertainties which may cause ourresults to differ materially and adversely from the statements contained herein. Some of the potential risks and uncertainties that could cause actual results to differ from those predicted include our ability to raise additional funding, our ability to acquire, develop or commercialize new products, uncertainties inherent in pre-clinical studies and clinical trials, unexpected new data, safety and technical issues, competition and market conditions. These and additional risks and uncertainties are more fully described in OncoSec’s filings with the Securities and Exchange Commission. Undue reliance should not be placed on forward looking statements which speak only as of the date they are made. OncoSec disclaims any obligation to update any forward looking statements to reflect new information, events or circumstances after the date they are made, or to reflect the occurrence of unanticipated events.

SAN DIEGO, Ca, March 28, 2012 — OncoSec Medical Incorporated (OTCBB: ONCS), which is developing its advanced-stage OncoSec Medical System (OMS) ElectroOncology therapies to treat solid tumor cancers, announced today the closing of the sale to institutional investors of an aggregate of 31,000,000 shares of its common stock at $0.25 per share in a registered public offering. Additionally, investors received Warrants to purchase up to 31,000,000 shares of common stock at an exercise price of $0.35 per share for a term of five years.

The gross proceeds of the offering were $7.75 million and net proceeds, after deducting the placement agent’s fee and estimated offering expenses payable by OncoSec, were approximately $7.2million.

OncoSec intends to use proceeds from the offering for general corporate purposes, including clinical trial expenses and research and development expenses.

Rodman & Renshaw, LLC, a subsidiary of Rodman & Renshaw Capital Group, Inc. (NASDAQ:RODMNews), acted as the exclusive placement agent for the transaction. Roth Capital Partners, LLC served as financial advisors to the Company in the offering.

About OncoSec Medical Inc.

OncoSec Medical Incorporated (OTCBB: ONCS) develops novel OMS ElectroOncology therapies that combine its proprietary electroporation delivery technology with a chemotherapeutic or novel DNA-based immunotherapeutics. Targeted local delivery of these agents is designed to achieve selective destruction of cancerous tumors while sparing healthy normal tissue, resulting in improved functional, cosmetic and quality of life outcomes. These therapieshave achieved validating safety and efficacy data in early and late stage clinical studies of over 400 cancer patients. OncoSec’s clinical programs include three Phase II clinical trials for OMS ElectroImmunotherapy. More information is available at www.oncosec.com. Additional information may also be found at OncoSec’s Facebook , Twitter, and LinkedIn sites.

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This press release contains forward looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Any statements in this release that are not historical facts may be considered such “forward looking statements.” Forward looking statements are based on management’s current preliminary expectations and are subject to risks and uncertainties which may cause ourresults to differ materially and adversely from the statements contained herein. Some of the potential risks and uncertainties that could cause actual results to differ from those predicted include our ability to raise additional funding, our ability to acquire, develop or commercialize new products, uncertainties inherent in pre-clinical studies and clinical trials, unexpected new data, safety and technical issues, competition and market conditions. These and additional risks and uncertainties are more fully described in OncoSec’s filings with the Securities and Exchange Commission. Undue reliance should not be placed on forward looking statements which speak only as of the date they are made. OncoSec disclaims any obligation to update any forward looking statements to reflect new information, events or circumstances after the date they are made, or to reflect the occurrence of unanticipated events.

Clinical Trial Designed to Validate Strong Safety and Efficacy Results Demonstrated in Phase I Study

SAN DIEGO, CA, February 28, 2012 — OncoSec Medical Incorporated (OTCBB: ONCS), which is developing its advanced-stage OncoSec Medical System (OMS) ElectroOncology therapies to treat solid tumor cancers, today announced that Investigational Review Board (IRB) approval has been received by the University of California San Francisco and the first patient has been dosed for a Phase II clinical trial evaluating OncoSec’s OMS ElectroImmunotherapy for the treatment of advanced stage cutaneous and in-transit metastatic melanoma. UCSF investigators are actively recruiting for this clinical trial.

“Results from our open-label Phase I study demonstrated that DNA IL-12 and electroporation has the potential to establish a new standard of care for the treatment of late-stage metastatic melanoma,” said Punit Dhillon, President and CEO of OncoSec. “With immune response results from this Phase II study expected in the second half of 2012, we are confident this study willvalidate the value of OMS ElectoImmunotherapy.”

A total of up to 25 patients with stage III or IV cutaneous and in-transit metastatic melanoma will be enrolled in this Phase II, single-arm, open-label and multi-center study. The trial is designed to assess local and distant objective response following treatment of cutaneous melanoma lesions with DNA IL-12 and electroporation with a primary endpoint of 24 weeks. One treatment cycle will consist of three treatments applied to up to four lesions on days 1, 5 and 8 with a maximum dose of 1.5 mg DNA IL-12 per treatment cycle. At 12 months, patients will be moved to the follow-up phase of the study and will be followed for up to five years for safety.

OMS ElectroImmunotherapy utilizes OncoSec’s proprietary technology to deliver a DNA-based cytokine coded for the immune stimulatingagent interleukin-12, or DNA IL-12. The OncoSec Medical System (OMS) applies short electric impulses to the tumor, causing pores to open in the membrane of cancer cells that significantly increases DNA IL-12 uptake into these cells. Phase I data using OMS ElectroImmunotherapy to treat malignant melanoma demonstrated that this therapy was safe and well tolerated. In addition, 53% of patients with distant metastatic lesions demonstrated an objective response, with 15% of these patients having a complete response to the treatment.

About OncoSec Medical Inc.

OncoSec Medical Incorporated (OTCBB: ONCS) develops novel OMS ElectroOncology therapies that combine its proprietary electroporation delivery technology with a chemotherapeutic or novel DNA-based immunotherapeutics. Targeted local delivery of these agents is designed to achieve selective destruction of cancerous tumors while sparing healthy normal tissue, resulting in improved functional, cosmetic and quality of life outcomes. These therapieshave achieved validating safety and efficacy data in early and late stage clinical studies of over 400 cancer patients. OncoSec’s clinical programs include three Phase II clinical trials for OMS ElectroImmunotherapy. More information is available at www.oncosec.com. Additional information may also be found at OncoSec’s Facebook , Twitter, and LinkedIn sites.

* * *

This press release contains forward looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Any statements in this release that are not historical facts may be considered such “forward looking statements.” Forward looking statements are based on management’s current preliminary expectations and are subject to risks and uncertainties which may cause ourresults to differ materially and adversely from the statements contained herein. Some of the potential risks and uncertainties that could cause actual results to differ from those predicted include our ability to raise additional funding, our ability to acquire, develop or commercialize new products, uncertainties inherent in pre-clinical studies and clinical trials, unexpected new data, safety and technical issues, competition and market conditions. These and additional risks and uncertainties are more fully described in OncoSec’s filings with the Securities and Exchange Commission. Undue reliance should not be placed on forward looking statements which speak only as of the date they are made. OncoSec disclaims any obligation to update any forward looking statements to reflect new information, events or circumstances after the date they are made, or to reflect the occurrence of unanticipated events.


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