OncoSec Medical to Present at the HemOnc Today Melanoma and Cutaneous Malignancies Meeting in New York

SAN DIEGO – March 18, 2013 — OncoSec Medical Inc. (OTCBB: ONCS), a company developing its advanced-stage ImmunoPulse DNA-based immunotherapy and NeoPulse therapy to treat solid tumor cancers, announced Dr. Adil Daud, chair of OncoSec’s Melanoma Advisory Board, will present at the HemOnc Today Melanoma and Cutaneous Malignancies Meeting at the Hilton New York Hotel on Friday, March 22 at 2:25 PM ET.

Dr. Daud will provide a presentation titled “Gene Therapy in Melanoma with pIL-12” and will review previously announced Phase I and II data from the ImmunoPulse clinical program in melanoma. More information can be found here: http://www.hemonctodaymelanoma.com/agenda.aspx#Fri

About the HemOnc Today Melanoma Meeting

 The HemOnc Today Melanoma Conference will feature more than 20 renowned speakers and 200 colleagues who will discuss pertinent aspects of management and biology of melanoma and other cutaneous malignancies.

The two-day event will feature expert perspectives from renowned specialists who have advanced expertise in oncology, dermatology and cutaneous malignancies and will explain how you can apply the new research and advances presented to your own patients and practice.

 

Thought-Leaders to Steer Development of the Company’s ImmunoPulse Program

SAN DIEGO – February 26, 2013 — OncoSec Medical Inc. (OTCBB: ONCS), a company developing its advanced-stage ImmunoPulse DNA-based immunotherapy and NeoPulse therapy to treat solid tumor cancers, announced the formation of a Melanoma Advisory Board (MAB) for the company’s metastatic melanoma program.

Bringing together a group of distinguished industry experts in the melanoma and immunotherapy space, the MAB will provide insight and expertise into OncoSec’s clinical strategies for the development of the company’s ImmunoPulse program for the treatment of metastatic melanoma.

Punit Dhillon, President and CEO of OncoSec, stated, “We have assembled an impressive group of thought-leaders who have unparalleled experience developing pioneering intralesional therapies. Their expertise will be invaluable in establishing electroporation as a premier delivery mechanism for gene therapies and ImmunoPulse as a first-in-class commercial treatment of aggressive metastatic disease.”

Chaired by Dr. Adil I. Daud, the MAB is comprised of five individuals:

Dr. Sanjiv S. Agarwala
Sanjiv K. Agarwala, M.D. is Chief of Medical Oncology & Hematology and Director of the Melanoma and Immunology Program at St. Luke’s Cancer Center, Bethlehem, PA. He is Professor of Medicine at Temple University School of Medicine, Philadelphia, PA. He is nationally and internationally recognized as an expert in the research and treatment of melanoma.

Dr. Adil I. Daud
Adil I. Daud, M.D. is a professor of medicine at the University of California San Francisco and a nationally recognized expert in early phase drug development in skin cancer and solid tumors. Prior to joining UCSF Medical Center, he was Associate Professor and Director of the Affiliate Network at the Moffitt Cancer Center in Tampa, FL for seven years. Dr. Daud has won numerous awards, including the American Society for Clinical Oncology’s Young Investigator Award.

Dr. Axel Hauschild
Axel Hauschild, M.D., Ph.D. is professor and head of the Interdisciplinary Skin Cancer
Center at the Department of Dermatology, University Hospital Schleswig-Holstein in Kiel, Germany. From 2002 to 2010 he was the chairman of the Dermatologic Cooperative Oncology Group (DeCOG) in Germany. Dr. Hauschild is a board member of the European Association of Dermato-Oncology (EADO) and the co-chairman of the Global Melanoma Task Force
(GMTF).

Dr. Kim A. Margolin
Kim A. Margolin, M.D. is Professor of Medicine at the University of Washington in Seattle and a member of the Clinical Research Division at the Fred Hutchinson Cancer Research Center. Dr. Margolin served as chair of the Cancer Education Committee for ASCO in 2010 and has previously served on the Board of Directors of the Society for Immunotherapy of Cancer, the Medical Oncology Boards subcommittee of the ABIM (2002-2008), and the Oncologic Drugs Advisory Committee to the FDA (1994-2000).

Dr. Vernon K. Sondak
Vernon K. Sondak, M.D. is Chair of the Department of Cutaneous Oncology and Director of Surgical Education at the H. Lee Moffitt Cancer Center and Research Institute in Tampa, FL. He is also a Professor in the Departments of Oncologic Sciences and Surgery at the University of South Florida Morsani College of Medicine.

Presentations on December 6 to Cover ImmunoPulse Therapy and Phase II Study of Melanoma Patients 

SAN DIEGO – December 04, 2012 — OncoSec Medical Inc. (OTCBB: ONCS), a company developing its advanced-stage ImmunoPulse DNA-based immunotherapy and NeoPulse therapy to treat solid tumor cancers, announced it will be presenting at the DNA Vaccines 2012 Conference at the Loews Coronado Bay Resort in San Diego, California. OncoSec is a Silver Sponsor of the conference.

The Company will conduct two presentations within the Cancer Immune Therapy Track on Thursday, December 6:

From 11:30 AM-12:00 PM PT, Richard Heller, Ph.D., director of the Frank Reidy Research Center for Bioelectrics at Old Dominion University, will speak on “Gene Electrotransfer for the Enhanced Delivery of Immunomodulating Agents.” In this presentation, Dr. Heller will present data on electroporation and delivery of plasmids for cancer immunotherapy, a technology used in OncoSec’s ImmunoPulse therapy.

From 12:00 PM-12:30 PM PT, Adil Daud, M.D., clinical professor of medicine and dermatology and director of the melanoma program at the University of California, San Francisco, will speak on “Clinical Studies of Melanoma Therapy.” In this presentation, Dr. Daud will be reviewing previously presented interim data from OncoSec’s ongoing Phase II trial for metastatic melanoma for which he is principal investigator.

The DNA Vaccines Conference brings in an array of researchers from all corners of the world to present new cutting-edge discoveries in DNA vaccines that have never before been presented or published at any other meeting. For more information about the conference, please visit: www.bioconferences.com/conferences/dna/index.aspx

 

 

95 Percent of All Treated Tumors Demonstrated Response to ImmunoPulse Therapy

SAN DIEGO – November 15, 2012 — OncoSec Medical Inc. (OTCBB: ONCS), a company developing its advanced-stage ImmunoPulse DNA-based immunotherapy and NeoPulse therapy to treat solid tumors, announces positive preliminary results from a Phase II trial investigating the use of ImmunoPulse in metastatic melanoma patients at the 6th World Meeting of Interdisciplinary Melanoma Skin Cancer Centres & 8th EADO Congress. This preliminary interim analysis of 13 out of 25 patients supports key findings from a Phase I trial suggesting that ImmunoPulse is able to induce regression or stabilization of distant untreated metastases following a single cycle of treatment.

A total of up to 25 patients with stage III or IV cutaneous and in-transit metastatic melanoma will be enrolled in this Phase II, single-arm, open-label and multi-center study. The trial was designed to assess local and distant objective response following treatment of cutaneous melanoma lesions with ImmunoPulse. As per the protocol, a preliminary interim analysis was scheduled upon completion of 50 percent enrollment in the study.

The purpose of the analysis was to confirm safety and efficacy observed in the Phase I study. At the time of this preliminary interim analysis, 13 patients were enrolled and treated. Thirteen subjects were evaluable at Day 39, nine at Day 90, and two at Day 180. Ninety-five percent of treated lesions demonstrated response at Day 39 (5 percent progressive disease, 14 percent stable disease (SD), 42 percent partial response (PR), 39 percent complete response (CR)). All treated lesions at Day 90 (5 percent SD, 50 percent PR, 45 percent CR), and at Day 180 (33 percent PR, 67 percent CR) demonstrated a response. At Day 180, two subjects were evaluable for the primary endpoint of objective overall response (ORR). One patient has a confirmed stable disease, and the second patient has a confirmed complete response of all treated and untreated lesions. Analysis of the safety data for the subjects analyzed confirms that intratumoral administration of DNA IL-12 with electroporation is safe and well-tolerated. No related adverse events reported were greater than grade 2, and were generally limited to transient pain related to electroporation treatment.

The preliminary results are being presented in a poster titled “Preliminary Analysis of a Phase II Trial of Intratumoral Delivery of Plasmid Interleukin-12  (pIL-12) with In Vivo Electroporation in Patients with Metastatic Melanoma.” Dr. Adil Daud, principal investigator and co-director of melanoma research at the University of California San Francisco School of Medicine, is co-author.

These data are also being orally presented at a parallel scientific symposium, hosted by OncoSec, titled “Electrogenetherapy: Intralesional Immunotherapy Approach for Skin Cancers Using Electroporation.” Drs. Adil Daud and Axel Hauschild will chair the event, which will be held on Thursday, November 15 from 6:00-7:00pm Barcelona time. The agenda is as follows:

– Application and Versatility of Electrogenetherapy – Dr. Richard Heller

– Clinical Experience: Case presentation and discussion of intralesional injection of

plasmid interleukin-12 with electroporation – Dr. Adil Daud

– Immune correlates and biomarkers: Immune related responses following intralesional injection of plasmid interleukin-12 with electroporation – Dr. David Weiner and Dr. Edward Cha

– Outlook on intralesional immunotherapies for the treatment of metastatic melanoma – Dr. Adil Daud

Punit Dhillon, President and CEO of OncoSec Medical, commented, “We are encouraged to have observed at least one complete response based on the evaluable patients that have met the primary endpoint timeline, and we will continue to follow this patient and the others to assess the durability of response. These data validate the results from the Phase I study and effort we have put into this program, while providing further evidence of the potential role of ImmunoPulse as a safe and effective option for treating this aggressive disease.”

Dr. Daud commented, “Preliminary results from this Phase II study appear to offer solid support to the earlier study indicating the efficacy of ImmunoPulse in treating metastatic melanoma. Enrollment in the study is ongoing and expected to be completed by the end of 2012. Long-term follow-up will assess durability of response.”

About the Phase II ImmunoPulse Study

A total of up to 25 patients with stage III or IV cutaneous and in-transit metastatic melanoma will be enrolled in this Phase II, single-arm, open-label and multi-center study. The trial is designed to assess local and distant objective response following treatment of cutaneous melanoma lesions with DNA IL-12 and electroporation with a primary endpoint of 24 weeks. One treatment cycle will consist of three treatments applied to up to four lesions on days 1, 5 and 8 with a maximum dose of 1.5 mg DNA IL-12 per treatment cycle. At 12 months, patients will be moved to the follow-up phase of the study and will be followed for up to five years for safety.

About Melanoma

Melanoma is the most serious form of skin cancer. If it is recognized and treated early, it is almost always curable, but if it is not, the cancer can advance and spread to other parts of the body, where it becomes hard to treat and can be fatal. While it is not the most common of the skin cancers, it causes the most deaths. The American Cancer Society estimates that at present, about 123,000 new cases of melanoma in the US are diagnosed in a year, resulting in approximately 10,000 deaths. Melanoma originates in melanocytes, the cells that produce the pigment melanin that colors our skin, hair, and eyes. The majority of melanomas are black or brown, but often they can also be skin-colored, pink, red, purple, blue or white. Currently, there remain few treatment options for patients with late-stage metastatic disease that can extend survival for the broad population.


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