ImmunoPulse™ IL-12

IMMUNOPULSE™ IL-12

To date, OncoSec’s immunotherapy platform, ImmunoPulse™, focuses on the delivery of DNA-based interleukin-12 (IL-12), a naturally occurring protein with immune-stimulating functions. The treatment is designed to produce a controlled, localized expression of IL-12 in the tumor microenvironment, which in turn, enables the immune system to target and attack tumors throughout the body.

OncoSec is currently investigating ImmunoPulse™ IL-12 for treatment of metastatic melanoma, head and neck cancer, and triple negative breast cancer. As the company continues to evaluate ImmunoPulse™ IL-12 in these current indications, OncoSec is developing new immune-targeting agents, investigating additional tumor indications, and evaluating combination-based immunotherapy approaches.

How it Works

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Cancer is identified in the body.

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DNA-based interleukin-12 (IL-12), a naturally occurring protein, is injected directly into the tumor.

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The applicator supplies a sequence of short-duration electrical pulses through a series of needles.

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Electrical pulses result in increased permeability of the cell membrane, allowing DNA-based IL-12 to enter.

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DNA-based IL-12 is expressed in the local tumor microenvironment.

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IL-12 drives local inflammatory response in the tumor.

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Immune cells are educated to recognize the patient’s cancer.

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Educated immune cells identify and attack tumors throughout the body.

Positive Results

Data from our multi-center Phase II trial of ImmunoPulse™ IL-12 demonstrated encouraging single-agent activity in 29 patients with metastatic melanoma.

Best Overall Response

Complete Response

Disease Control Rate

Patients Showing Complete Regression in at Least One Untreated Lesion